A rapid technique for producing ethanol dependence in the rat

Dale S. Cannon, Timothy B. Baker, Robert F Berman, Carol A. Atkinson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Ethanol dependence in the rat is demonstrated following 2-4 days of intragastric intubation with 8-12 g/kg/day. Withdrawal symptoms include tremulousness, hyperactivity, and seizures. Nutritional deficiency is shown to be an insufficient explanation of the withdrawal symptoms produced.

Original languageEnglish (US)
Pages (from-to)831-834
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number6
StatePublished - 1974
Externally publishedYes


  • Dependence
  • Ethanol
  • Rat
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology


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