A randomized stepped care intervention trial targeting posttraumatic stress disorder for surgically hospitalized injury survivors

Douglas Zatzick, Gregory Jurkovich, Frederick P. Rivara, Joan Russo, Amy Wagner, Jin Wang, Chris Dunn, Sarah Peregrine Lord, Megan Petrie, Stephen S. O'Connor, Wayne Katon

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective:: To test the effectiveness of a stepped care intervention model targeting posttraumatic stress disorder (PTSD) symptoms after injury. Background:: Few investigations have evaluated interventions for injured patients with PTSD and related impairments that can be feasibly implemented in trauma surgical settings. METHODS:: The investigation was a pragmatic effectiveness trial in which 207 acutely injured hospitalized trauma survivors were screened for high PTSD symptom levels and then randomized to a stepped combined care management, psychopharmacology, and cognitive behavioral psychotherapy intervention (n = 104) or usual care control (n = 103) conditions. The symptoms of PTSD and functional limitations were reassessed at 1, 3, 6, 9, and 12 months after the index injury admission. RESULTS:: Regression analyses demonstrated that over the course of the year after injury, intervention patients had significantly reduced PTSD symptoms when compared with controls [group by time effect, CAPS (Clinician-Administered PTSD Scale): F(2, 185) = 5.50, P < 0.01; PCL-C (PTSD Checklist Civilian Version): F(4, 185) = 5.45, P < 0.001]. Clinically and statistically significant PTSD treatment effects were observed at the 6-, 9-, and 12-month postinjury assessments. Over the course of the year after injury, intervention patients also demonstrated significant improvements in physical function [MOS SF-36 PCS (Medical Outcomes Study Short Form 36 Physical Component Summary) main effect: F(1, 172) = 9.87, P < 0.01]. CONCLUSIONS:: Stepped care interventions can reduce PTSD symptoms and improve functioning over the course of the year after surgical injury hospitalization. Orchestrated investigative and policy efforts could systematically introduce and evaluate screening and intervention procedures for PTSD at US trauma centers. (Trial Registration: clinicaltrials.gov identifier: NCT00270959)

Original languageEnglish (US)
Pages (from-to)390-399
Number of pages10
JournalAnnals of Surgery
Volume257
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Post-Traumatic Stress Disorders
Survivors
Wounds and Injuries
Pragmatic Clinical Trials
Psychopharmacology
Trauma Centers
Intraoperative Complications
Cognitive Therapy
Checklist
Hospitalization
Regression Analysis
Outcome Assessment (Health Care)
Control Groups

Keywords

  • injury
  • physical function
  • PTSD
  • stepped care
  • surgical hospitalization
  • traumatic brain injury

ASJC Scopus subject areas

  • Surgery

Cite this

A randomized stepped care intervention trial targeting posttraumatic stress disorder for surgically hospitalized injury survivors. / Zatzick, Douglas; Jurkovich, Gregory; Rivara, Frederick P.; Russo, Joan; Wagner, Amy; Wang, Jin; Dunn, Chris; Lord, Sarah Peregrine; Petrie, Megan; O'Connor, Stephen S.; Katon, Wayne.

In: Annals of Surgery, Vol. 257, No. 3, 01.03.2013, p. 390-399.

Research output: Contribution to journalArticle

Zatzick, D, Jurkovich, G, Rivara, FP, Russo, J, Wagner, A, Wang, J, Dunn, C, Lord, SP, Petrie, M, O'Connor, SS & Katon, W 2013, 'A randomized stepped care intervention trial targeting posttraumatic stress disorder for surgically hospitalized injury survivors', Annals of Surgery, vol. 257, no. 3, pp. 390-399. https://doi.org/10.1097/SLA.0b013e31826bc313
Zatzick, Douglas ; Jurkovich, Gregory ; Rivara, Frederick P. ; Russo, Joan ; Wagner, Amy ; Wang, Jin ; Dunn, Chris ; Lord, Sarah Peregrine ; Petrie, Megan ; O'Connor, Stephen S. ; Katon, Wayne. / A randomized stepped care intervention trial targeting posttraumatic stress disorder for surgically hospitalized injury survivors. In: Annals of Surgery. 2013 ; Vol. 257, No. 3. pp. 390-399.
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AU - Dunn, Chris

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