A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with ≤400/mm 3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137)

Fred T. Valentine, Smriti Kundu, Patrick A J Haslett, David Katzenstein, Laurel A Beckett, Cathie Spino, Michael Borucki, Margarita Vasquez, Gale Smith, Joyce Korvick, Jonathan Kagan, Thomas C. Merigan

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Immune responses provoked by human immunodeficiency virus (HIV) infection ultimately are insufficient to control the disease and do not include strong lymphocyte-proliferative responses to HIV antigens or antibodies to many vital epitopes. A randomized double-blind, placebo- controlled trial evaluated the immunogenicity of recombinant HIV envelope vaccine (rgp160) in HIV-infected subjects with ≤400/mm 3 CD4 T cells. Controls received hepatitis B vaccine. Of subjects receiving rgp160, 98% developed lymphocyte-proliferative responses to the immunogen, 33% to a different envelope protein, and 56% and 60% to p24 and p66, respectively. All doses of vaccine (20, 80, 320, 1280 μg) induced new responses. New antibodies to epitopes on rgp160 developed only in recipients of higher doses of rgp160. CD4 T cell percentages declined less rapidly in recipients of rgp160 than in controls. Vaccination of HIV-infected subjects with rgp160 results in cellular and humoral immune responses to HIV that infection itself had not stimulated.

Original languageEnglish (US)
Pages (from-to)1336-1346
Number of pages11
JournalJournal of Infectious Diseases
Volume173
Issue number6
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Valentine, F. T., Kundu, S., Haslett, P. A. J., Katzenstein, D., Beckett, L. A., Spino, C., Borucki, M., Vasquez, M., Smith, G., Korvick, J., Kagan, J., & Merigan, T. C. (1996). A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with ≤400/mm 3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137). Journal of Infectious Diseases, 173(6), 1336-1346.