A randomized placebo-controlled crossover trial of aloe vera on bioavailability of Vitamins C and B 12, blood glucose, and lipid profile in healthy human subjects

Jung Mi Yun, Sital Singh, Rohan Jialal, Jason Rockwood, Ishwarlal Jialal, Sridevi Devaraj

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Several factors limit the absorption and bioavailability of vitamins. Vitamin C, a commonly used water-soluble supplement reduces the risk of disease. Vitamin B 12 is necessary for the development of RBC, growth, and nervous system. Vitamin B 12 deficiency is common among elderly. Thus, agents that improve bioavailability of vitamin C and B 12, especially in older individuals would be important. Aloe Vera is a botanical with immunomodulatory properties. Aloe is processed using the hand-filleted technique or whole leaf procedure. The aim of this study is to examine the effect of two different aloe vera preparations (aloe inner leaf gel, AG and aloe whole leaf decolorized gel, AL) compared to placebo on the bioavailability of vitamins, C and B 12, in healthy human volunteers in a randomized crossover trial. Subjects (n = 15) received in a random fashion either aloe whole leaf extract (AL with vitamins B 12, 1 mg and vitamin C 500 mg) or aloe fillet gel (AG with B 12 1 mg and vitamin C 500 mg) or water (with vitamin B 12 1 mg and vitamin C 500 mg). Blood was obtained fasting, followed by 1, 2, 4, 6, 8, and 24 hours postingestion of aloe/water. When given with vitamins C and B 12, AG significantly increased plasma oxygen radical absorbance capacity (ORAC) at both 4 and 24 hours and AL at 4 hours compared to baseline and placebo. AG significantly increased plasma vitamin C at 4, 6, 8, and 24 hours and AL at 4 and 6 hours compared to baseline and placebo (p <.01). Also, both aloes significantly increased serum vitamin B 12 levels at 1 and 2 hours compared to baseline and placebo (p <.01). Thus, AG and AL preparations are safe, well tolerated, and enhance the bioavailability of vitamins C and B 12 and antioxidant potential.

Original languageEnglish (US)
Pages (from-to)145-153
Number of pages9
JournalJournal of Dietary Supplements
Volume7
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Aloe
  • Bioavailability
  • Elderly
  • Gel
  • Vitamins
  • Whole leaf

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Pharmacology (medical)

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