A Randomized Effectiveness Trial of Stepped Collaborative Care for Acutely Injured Trauma Survivors

Douglas Zatzick, Peter Roy-Byrne, Joan Russo, Frederick Rivara, Rose Anne Droesch, Amy Wagner, Chris Dunn, Gregory Jurkovich, Edwina Uehara, Wayne Katon

Research output: Contribution to journalArticlepeer-review

239 Scopus citations


Context: Although posttraumatic stress disorder (PTSD) and alcohol abuse frequently occur among acutely injured trauma survivors, few real-world interventions have targeted these disorders. Objective: We tested the effectiveness of a multifaceted collaborative care (CC) intervention for PTSD and alcohol abuse. Design: Randomized effectiveness trial. Participants: We recruited a population-based sample of 120 male and female injured surgical inpatients 18 or older at a level I trauma center. Intervention: Patients were randomly assigned to the CC intervention (n = 59) or the usual care (UC) control condition (n = 61). The CC patients received stepped care that consisted of (1) continuous postinjury case management, (2) motivational interviews targeting alcohol abuse/dependence, and (3) evidence-based pharmacotherapy and/or cognitive behavioral therapy for patients with persistent PTSD at 3 months after injury. Main Outcome Measures: We used the PTSD symptomatic criteria (PTSD Checklist) at baseline and 1, 3, 6, and 12 months after injury, and alcohol abuse/dependence (Composite International Diagnostic Interview) at baseline and 6 and 12 months after injury. Results: Random-coefficient regression analyses demonstrated that over time, CC patients were significantly less symptomatic compared with UC patients with regard to PTSD (P = .01) and alcohol abuse/dependence (P = .048). The CC group demonstrated no difference (-0.07%; 95% confidence interval [CI], -4.2% to 4.3%) in the adjusted rates of change in PTSD from baseline to 12 months, whereas the UC group had a 6% increase (95% CI, 3.1%-9.3%) during the year. The CC group showed on average a decrease in the rate of alcohol abuse/dependence of -24.2% (95% CI, -19.9% to -28.6%), whereas the UC group had on average a 12.9% increase (95% CI, 8.2%-17.7%) during the year. Conclusions: Early mental health care interventions can be feasibly and effectively delivered from trauma centers. Future investigations that refine routine acute care treatment procedures may improve the quality of mental health care for Americans injured in the wake of individual and mass trauma.

Original languageEnglish (US)
Pages (from-to)498-506
Number of pages9
JournalArchives of General Psychiatry
Issue number5
StatePublished - May 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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