Abstract
This prospective, randomized, multicenter, controlled trial was designed to evaluate the efficacy and safety of intravenous ganciclovir for the treatment of peripheral cytomegalovirus (CMV) retinitis in patients with AIDS. Patients were randomly assigned to receive either immediate treatment, intravenous ganciclovir, 5 mg/kg twice daily for 14 days followed by 5 mg/kg once daily for 14 weeks, or deferred treatment. Patients randomized to deferred treatment whose retinitis progressed were offered ganciclovir. Of the 22 patients randomized to deferred treatment who were included in the final analysis, 20 were found to have progressive CMV retinitis compared with 10 of the 13 randomized to immediate treatment. The median time to progression in the deferred treatment group, as determined by a masked fundus photography reading center, was 13.5 days compared with 49.5 days in the immediate treatment group (mean ± SD, 19.3 ± 4.1 vs. 66.4 ± 14.0; P = .001, log rank test). These data indicate that ganciclovir delays the progression of CMV peripheral retinitis in persons with AIDS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 557-563 |
| Number of pages | 7 |
| Journal | Journal of Infectious Diseases |
| Volume | 168 |
| Issue number | 3 |
| State | Published - Sep 1993 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. / Spector, Stephen A.; Weingeist, Thomas; Pollard, Richard B; Dieterich, Douglas T.; Samo, Tobias; Benson, Constance A.; Busch, David F.; Freeman, William R.; Montague, Paul; Kaplan, Henry J.; Kellerman, Lois; Crager, Michael; De Armond, Bernadette; Buhles, William; Feinberg, Judith.
In: Journal of Infectious Diseases, Vol. 168, No. 3, 09.1993, p. 557-563.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS
AU - Spector, Stephen A.
AU - Weingeist, Thomas
AU - Pollard, Richard B
AU - Dieterich, Douglas T.
AU - Samo, Tobias
AU - Benson, Constance A.
AU - Busch, David F.
AU - Freeman, William R.
AU - Montague, Paul
AU - Kaplan, Henry J.
AU - Kellerman, Lois
AU - Crager, Michael
AU - De Armond, Bernadette
AU - Buhles, William
AU - Feinberg, Judith
PY - 1993/9
Y1 - 1993/9
N2 - This prospective, randomized, multicenter, controlled trial was designed to evaluate the efficacy and safety of intravenous ganciclovir for the treatment of peripheral cytomegalovirus (CMV) retinitis in patients with AIDS. Patients were randomly assigned to receive either immediate treatment, intravenous ganciclovir, 5 mg/kg twice daily for 14 days followed by 5 mg/kg once daily for 14 weeks, or deferred treatment. Patients randomized to deferred treatment whose retinitis progressed were offered ganciclovir. Of the 22 patients randomized to deferred treatment who were included in the final analysis, 20 were found to have progressive CMV retinitis compared with 10 of the 13 randomized to immediate treatment. The median time to progression in the deferred treatment group, as determined by a masked fundus photography reading center, was 13.5 days compared with 49.5 days in the immediate treatment group (mean ± SD, 19.3 ± 4.1 vs. 66.4 ± 14.0; P = .001, log rank test). These data indicate that ganciclovir delays the progression of CMV peripheral retinitis in persons with AIDS.
AB - This prospective, randomized, multicenter, controlled trial was designed to evaluate the efficacy and safety of intravenous ganciclovir for the treatment of peripheral cytomegalovirus (CMV) retinitis in patients with AIDS. Patients were randomly assigned to receive either immediate treatment, intravenous ganciclovir, 5 mg/kg twice daily for 14 days followed by 5 mg/kg once daily for 14 weeks, or deferred treatment. Patients randomized to deferred treatment whose retinitis progressed were offered ganciclovir. Of the 22 patients randomized to deferred treatment who were included in the final analysis, 20 were found to have progressive CMV retinitis compared with 10 of the 13 randomized to immediate treatment. The median time to progression in the deferred treatment group, as determined by a masked fundus photography reading center, was 13.5 days compared with 49.5 days in the immediate treatment group (mean ± SD, 19.3 ± 4.1 vs. 66.4 ± 14.0; P = .001, log rank test). These data indicate that ganciclovir delays the progression of CMV peripheral retinitis in persons with AIDS.
UR - http://www.scopus.com/inward/record.url?scp=0027320067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027320067&partnerID=8YFLogxK
M3 - Article
C2 - 8394858
AN - SCOPUS:0027320067
VL - 168
SP - 557
EP - 563
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -