A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy

V. C. Magni, R. A. Frost, Joseph Leung, P. B. Cotton

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endpscopy. Sedation and conditions for examination were comparablè and satisfactory in both groups. Midazolam produced more amnmia (P= <0.001), and scored higher in patients' opinion (P= <0.001); it was associated with a slightly greater frequency of venous sequelae, but the difference in thrombophlebitis was not statistically significant. Recovery of sensory - motor performance, as assessed by Trieger test, was still incomplete 2 h after endoscopy with, both drug regimens.

Original languageEnglish (US)
Pages (from-to)1095-1101
Number of pages7
JournalBritish Journal of Anaesthesia
Volume55
Issue number11
DOIs
StatePublished - Nov 1983
Externally publishedYes

Fingerprint

Midazolam
gastrointestinal endoscopy
pethidine
Endoscopy
Meperidine
Gastrointestinal Endoscopy
diazepam
sedation
Diazepam
Emulsions
thrombophlebitis
Psychomotor Performance
Recovery
Thrombophlebitis
Emulsion
endoscopy
complications (disease)
emulsions
Drugs
drugs

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy. / Magni, V. C.; Frost, R. A.; Leung, Joseph; Cotton, P. B.

In: British Journal of Anaesthesia, Vol. 55, No. 11, 11.1983, p. 1095-1101.

Research output: Contribution to journalArticle

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