A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy

V. C. Magni; R. A. Frost; Joseph Leung; P. B. Cotton

doi:10.1093/bja/55.11.1095

A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy

V. C. Magni, R. A. Frost, Joseph Leung, P. B. Cotton

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endpscopy. Sedation and conditions for examination were comparablè and satisfactory in both groups. Midazolam produced more amnmia (P= <0.001), and scored higher in patients' opinion (P= <0.001); it was associated with a slightly greater frequency of venous sequelae, but the difference in thrombophlebitis was not statistically significant. Recovery of sensory - motor performance, as assessed by Trieger test, was still incomplete 2 h after endoscopy with, both drug regimens.

Original language	English (US)
Pages (from-to)	1095-1101
Number of pages	7
Journal	British Journal of Anaesthesia
Volume	55
Issue number	11
DOIs	https://doi.org/10.1093/bja/55.11.1095
State	Published - Nov 1983
Externally published	Yes

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Mathematics(all)
Statistics and Probability
Agricultural and Biological Sciences (miscellaneous)
Anesthesiology and Pain Medicine

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