A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy

V. C. Magni, R. A. Frost, Joseph Leung, P. B. Cotton

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endpscopy. Sedation and conditions for examination were comparablè and satisfactory in both groups. Midazolam produced more amnmia (P= <0.001), and scored higher in patients' opinion (P= <0.001); it was associated with a slightly greater frequency of venous sequelae, but the difference in thrombophlebitis was not statistically significant. Recovery of sensory - motor performance, as assessed by Trieger test, was still incomplete 2 h after endoscopy with, both drug regimens.

Original languageEnglish (US)
Pages (from-to)1095-1101
Number of pages7
JournalBritish Journal of Anaesthesia
Volume55
Issue number11
DOIs
StatePublished - Nov 1983
Externally publishedYes

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

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