A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin, Mark W. Groch, Daniel J. Macey, Gerald L Denardo, Sally J. DeNardo, Sui Shen

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)525-532
Number of pages8
JournalNuclear Medicine and Biology
Volume23
Issue number4
DOIs
StatePublished - May 1996

Fingerprint

Radioimmunodetection
Radioimmunotherapy
Radioisotopes
Clinical Medicine
Nuclear Medicine
Anger
Adenocarcinoma
Breast
B-Lymphocytes
Software
Radiation
Therapeutics
Neoplasms

Keywords

  • Dosimetry
  • MIRD
  • Monoclonal antibodies
  • Radioimmunoimaging
  • Radioimmunotherapy
  • Treatment planning

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy. / Erwin, William D.; Groch, Mark W.; Macey, Daniel J.; Denardo, Gerald L; DeNardo, Sally J.; Shen, Sui.

In: Nuclear Medicine and Biology, Vol. 23, No. 4, 05.1996, p. 525-532.

Research output: Contribution to journalArticle

Erwin, William D. ; Groch, Mark W. ; Macey, Daniel J. ; Denardo, Gerald L ; DeNardo, Sally J. ; Shen, Sui. / A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy. In: Nuclear Medicine and Biology. 1996 ; Vol. 23, No. 4. pp. 525-532.
@article{2b23100a91d14621a454884dbfa85679,
title = "A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy",
abstract = "A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.",
keywords = "Dosimetry, MIRD, Monoclonal antibodies, Radioimmunoimaging, Radioimmunotherapy, Treatment planning",
author = "Erwin, {William D.} and Groch, {Mark W.} and Macey, {Daniel J.} and Denardo, {Gerald L} and DeNardo, {Sally J.} and Sui Shen",
year = "1996",
month = "5",
doi = "10.1016/0969-8051(96)00036-4",
language = "English (US)",
volume = "23",
pages = "525--532",
journal = "Nuclear Medicine and Biology",
issn = "0969-8051",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

AU - Erwin, William D.

AU - Groch, Mark W.

AU - Macey, Daniel J.

AU - Denardo, Gerald L

AU - DeNardo, Sally J.

AU - Shen, Sui

PY - 1996/5

Y1 - 1996/5

N2 - A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

AB - A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

KW - Dosimetry

KW - MIRD

KW - Monoclonal antibodies

KW - Radioimmunoimaging

KW - Radioimmunotherapy

KW - Treatment planning

UR - http://www.scopus.com/inward/record.url?scp=0030152864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030152864&partnerID=8YFLogxK

U2 - 10.1016/0969-8051(96)00036-4

DO - 10.1016/0969-8051(96)00036-4

M3 - Article

C2 - 8832711

AN - SCOPUS:0030152864

VL - 23

SP - 525

EP - 532

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 4

ER -