Abstract
A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 525-532 |
| Number of pages | 8 |
| Journal | Nuclear Medicine and Biology |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1996 |
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Keywords
- Dosimetry
- MIRD
- Monoclonal antibodies
- Radioimmunoimaging
- Radioimmunotherapy
- Treatment planning
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy. / Erwin, William D.; Groch, Mark W.; Macey, Daniel J.; Denardo, Gerald L; DeNardo, Sally J.; Shen, Sui.
In: Nuclear Medicine and Biology, Vol. 23, No. 4, 05.1996, p. 525-532.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy
AU - Erwin, William D.
AU - Groch, Mark W.
AU - Macey, Daniel J.
AU - Denardo, Gerald L
AU - DeNardo, Sally J.
AU - Shen, Sui
PY - 1996/5
Y1 - 1996/5
N2 - A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.
AB - A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.
KW - Dosimetry
KW - MIRD
KW - Monoclonal antibodies
KW - Radioimmunoimaging
KW - Radioimmunotherapy
KW - Treatment planning
UR - http://www.scopus.com/inward/record.url?scp=0030152864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030152864&partnerID=8YFLogxK
U2 - 10.1016/0969-8051(96)00036-4
DO - 10.1016/0969-8051(96)00036-4
M3 - Article
C2 - 8832711
AN - SCOPUS:0030152864
VL - 23
SP - 525
EP - 532
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 4
ER -