A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin, Mark W. Groch, Daniel J. Macey, Gerald L Denardo, Sally J. DeNardo, Sui Shen

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)525-532
Number of pages8
JournalNuclear Medicine and Biology
Volume23
Issue number4
DOIs
StatePublished - May 1996

    Fingerprint

Keywords

  • Dosimetry
  • MIRD
  • Monoclonal antibodies
  • Radioimmunoimaging
  • Radioimmunotherapy
  • Treatment planning

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this