A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin; Mark W. Groch; Daniel J. Macey; Gerald L Denardo; Sally J. DeNardo; Sui Shen

doi:10.1016/0969-8051(96)00036-4

A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin, Mark W. Groch, Daniel J. Macey, Gerald L Denardo, Sally J. DeNardo, Sui Shen

Research

Research output: Contribution to journal › Article

41 Scopus citations

Abstract

A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for ¹³¹I, ⁶⁷Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

Original language	English (US)
Pages (from-to)	525-532
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/0969-8051(96)00036-4
State	Published - May 1996

Keywords

Dosimetry
MIRD
Monoclonal antibodies
Radioimmunoimaging
Radioimmunotherapy
Treatment planning

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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Erwin, W. D., Groch, M. W., Macey, D. J., Denardo, G. L., DeNardo, S. J., & Shen, S. (1996). A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy. Nuclear Medicine and Biology, 23(4), 525-532. https://doi.org/10.1016/0969-8051(96)00036-4

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