A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin; Mark W. Groch; Daniel J. Macey; Gerald L Denardo; Sally J. DeNardo; Sui Shen

doi:10.1016/0969-8051(96)00036-4

A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

William D. Erwin, Mark W. Groch, Daniel J. Macey, Gerald L Denardo, Sally J. DeNardo, Sui Shen

Research

Research output: Contribution to journal › Article

41 Scopus citations

Abstract

A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for ¹³¹I, ⁶⁷Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

Original language	English (US)
Pages (from-to)	525-532
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/0969-8051(96)00036-4
State	Published - May 1996

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Keywords

Dosimetry
MIRD
Monoclonal antibodies
Radioimmunoimaging
Radioimmunotherapy
Treatment planning

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Cite this

Erwin, W. D., Groch, M. W., Macey, D. J., Denardo, G. L., DeNardo, S. J., & Shen, S. (1996). A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy. Nuclear Medicine and Biology, 23(4), 525-532. https://doi.org/10.1016/0969-8051(96)00036-4

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10.1016/0969-8051(96)00036-4