Abstract
Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 390-393 |
| Number of pages | 4 |
| Journal | Ticks and Tick-borne Diseases |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Dog
- Horse
- Host-niche polymorphism
- Ixodes pacificus
- Tick-borne disease
ASJC Scopus subject areas
- Infectious Diseases
- Insect Science
- Parasitology
- Microbiology
Cite this
A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism. / Foley, Janet E; Stephenson, Nicole; Cubilla, Michelle Pires; Qurollo, Barbara; Breitschwerdt, Edward B.
In: Ticks and Tick-borne Diseases, Vol. 7, No. 2, 01.03.2016, p. 390-393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism
AU - Foley, Janet E
AU - Stephenson, Nicole
AU - Cubilla, Michelle Pires
AU - Qurollo, Barbara
AU - Breitschwerdt, Edward B.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.
AB - Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.
KW - Dog
KW - Horse
KW - Host-niche polymorphism
KW - Ixodes pacificus
KW - Tick-borne disease
UR - http://www.scopus.com/inward/record.url?scp=84958910330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958910330&partnerID=8YFLogxK
U2 - 10.1016/j.ttbdis.2015.12.015
DO - 10.1016/j.ttbdis.2015.12.015
M3 - Article
C2 - 26748871
AN - SCOPUS:84958910330
VL - 7
SP - 390
EP - 393
JO - Ticks and Tick-borne Diseases
JF - Ticks and Tick-borne Diseases
SN - 1877-959X
IS - 2
ER -