A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism

Janet E Foley, Nicole Stephenson, Michelle Pires Cubilla, Barbara Qurollo, Edward B. Breitschwerdt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalTicks and Tick-borne Diseases
Volume7
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • Dog
  • Horse
  • Host-niche polymorphism
  • Ixodes pacificus
  • Tick-borne disease

ASJC Scopus subject areas

  • Infectious Diseases
  • Insect Science
  • Parasitology
  • Microbiology

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