A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism

Janet E Foley; Nicole Stephenson; Michelle Pires Cubilla; Barbara Qurollo; Edward B. Breitschwerdt

doi:10.1016/j.ttbdis.2015.12.015

A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism

Janet E Foley, Nicole Stephenson, Michelle Pires Cubilla, Barbara Qurollo, Edward B. Breitschwerdt

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.

Original language	English (US)
Pages (from-to)	390-393
Number of pages	4
Journal	Ticks and Tick-borne Diseases
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.ttbdis.2015.12.015
State	Published - Mar 1 2016

Keywords

Dog
Horse
Host-niche polymorphism
Ixodes pacificus
Tick-borne disease

ASJC Scopus subject areas

Infectious Diseases
Insect Science
Parasitology
Microbiology

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10.1016/j.ttbdis.2015.12.015

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A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism. / Foley, Janet E; Stephenson, Nicole; Cubilla, Michelle Pires; Qurollo, Barbara; Breitschwerdt, Edward B.

In: Ticks and Tick-borne Diseases, Vol. 7, No. 2, 01.03.2016, p. 390-393.

Research output: Contribution to journal › Article › peer-review

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AU - Breitschwerdt, Edward B.

PY - 2016/3/1

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AB - Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains suggested that "drhm", a gene locus designated "distantly related to human marker" (drhm), which was predicted to be an integral membrane protein with possible transporter functions was not present in available canine and human isolates. By assessing 117 strains from 14 host species from across the US, we extended this analysis. Phylogenetic clades were associated with geography, but not host species. Additionally, a virulent clade that lacks drhm and infects dogs, horses, and humans in northeastern US was identified.

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A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism

Abstract

Keywords

ASJC Scopus subject areas

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