Abstract
Pharmacokinetics of vancomycin and dosage requirements were evaluated prospectively in 28 pediatric cancer patients 9 months to 13 years of age. The predictive performance of a two- compartment Bayesian forecasting program was also evaluated. A mean (±SD) daily dosage of 75 ± 22 mg/kg/day was necessary to attain a mean peak serum vancomycin concentration (SVC) of 23.1 ± 5.8 mg/liter and a mean trough SVC of 6.2 ± 2.3 mg/liter. Mean vancomycin clearance, volume of distribution and serum half-life were 0.153 ± 0.033 liter/hour/kg, 0.63 ± 0.08 liter/kg and 2.95 ± 0.48 hours. Final peak SVCs, which reflected the last dosage regimens received, were predicted with minimal bias (mean prediction error, -1.2 mg/liter) and accurate precision (root mean- squared prediction error, 2.0 mg/liter) whereas trough SVCs were predicted with even smaller bias (mean prediction error, -0.1 mg/liter) and greater precision (root mean-squared prediction error, 0.8 mg/liter). This study showed that pediatric cancer patients with normal renal function required vancomycin dosage regimens substantially greater than the standard 40 mg/kg/day to attain the desired SVCs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 969-974 |
| Number of pages | 6 |
| Journal | Pediatric Infectious Disease Journal |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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Keywords
- Bayesian pharmacokinetics
- Cancer patients
- Pediatric
- Vancomycin dosage
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Microbiology (medical)
- Infectious Diseases
Cite this
A prospective study of vancomycin pharmacokinetics and dosage requirements in pediatric cancer patients. / Chang, Donald; Liem, Lorraine; Malogolowkin, Marcio.
In: Pediatric Infectious Disease Journal, Vol. 13, No. 11, 01.01.1994, p. 969-974.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A prospective study of vancomycin pharmacokinetics and dosage requirements in pediatric cancer patients
AU - Chang, Donald
AU - Liem, Lorraine
AU - Malogolowkin, Marcio
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Pharmacokinetics of vancomycin and dosage requirements were evaluated prospectively in 28 pediatric cancer patients 9 months to 13 years of age. The predictive performance of a two- compartment Bayesian forecasting program was also evaluated. A mean (±SD) daily dosage of 75 ± 22 mg/kg/day was necessary to attain a mean peak serum vancomycin concentration (SVC) of 23.1 ± 5.8 mg/liter and a mean trough SVC of 6.2 ± 2.3 mg/liter. Mean vancomycin clearance, volume of distribution and serum half-life were 0.153 ± 0.033 liter/hour/kg, 0.63 ± 0.08 liter/kg and 2.95 ± 0.48 hours. Final peak SVCs, which reflected the last dosage regimens received, were predicted with minimal bias (mean prediction error, -1.2 mg/liter) and accurate precision (root mean- squared prediction error, 2.0 mg/liter) whereas trough SVCs were predicted with even smaller bias (mean prediction error, -0.1 mg/liter) and greater precision (root mean-squared prediction error, 0.8 mg/liter). This study showed that pediatric cancer patients with normal renal function required vancomycin dosage regimens substantially greater than the standard 40 mg/kg/day to attain the desired SVCs.
AB - Pharmacokinetics of vancomycin and dosage requirements were evaluated prospectively in 28 pediatric cancer patients 9 months to 13 years of age. The predictive performance of a two- compartment Bayesian forecasting program was also evaluated. A mean (±SD) daily dosage of 75 ± 22 mg/kg/day was necessary to attain a mean peak serum vancomycin concentration (SVC) of 23.1 ± 5.8 mg/liter and a mean trough SVC of 6.2 ± 2.3 mg/liter. Mean vancomycin clearance, volume of distribution and serum half-life were 0.153 ± 0.033 liter/hour/kg, 0.63 ± 0.08 liter/kg and 2.95 ± 0.48 hours. Final peak SVCs, which reflected the last dosage regimens received, were predicted with minimal bias (mean prediction error, -1.2 mg/liter) and accurate precision (root mean- squared prediction error, 2.0 mg/liter) whereas trough SVCs were predicted with even smaller bias (mean prediction error, -0.1 mg/liter) and greater precision (root mean-squared prediction error, 0.8 mg/liter). This study showed that pediatric cancer patients with normal renal function required vancomycin dosage regimens substantially greater than the standard 40 mg/kg/day to attain the desired SVCs.
KW - Bayesian pharmacokinetics
KW - Cancer patients
KW - Pediatric
KW - Vancomycin dosage
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U2 - 10.1097/00006454-199411000-00007
DO - 10.1097/00006454-199411000-00007
M3 - Article
VL - 13
SP - 969
EP - 974
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 11
ER -