A prospective study of fruits, vegetables, and risk of endometrial cancer

Marjorie L. McCullough, Elisa V. Bandera, Roshni Patel, Alpa V. Patel, Ted Gansler, Lawrence H. Kushi, Michael J. Thun, Eugenia E. Calle

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95% confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95% CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95% CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95% CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer.

Original languageEnglish (US)
Pages (from-to)902-911
Number of pages10
JournalAmerican Journal of Epidemiology
Volume166
Issue number8
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Endometrial Neoplasms
Vegetables
Fruit
Prospective Studies
Confidence Intervals
Diet
Hormone Replacement Therapy
Case-Control Studies
Life Style
Neoplasms

Keywords

  • Cohort studies
  • Endometrial neoplasms
  • Fruit
  • Vegetables

ASJC Scopus subject areas

  • Epidemiology

Cite this

McCullough, M. L., Bandera, E. V., Patel, R., Patel, A. V., Gansler, T., Kushi, L. H., ... Calle, E. E. (2007). A prospective study of fruits, vegetables, and risk of endometrial cancer. American Journal of Epidemiology, 166(8), 902-911. https://doi.org/10.1093/aje/kwm156

A prospective study of fruits, vegetables, and risk of endometrial cancer. / McCullough, Marjorie L.; Bandera, Elisa V.; Patel, Roshni; Patel, Alpa V.; Gansler, Ted; Kushi, Lawrence H.; Thun, Michael J.; Calle, Eugenia E.

In: American Journal of Epidemiology, Vol. 166, No. 8, 10.2007, p. 902-911.

Research output: Contribution to journalArticle

McCullough, ML, Bandera, EV, Patel, R, Patel, AV, Gansler, T, Kushi, LH, Thun, MJ & Calle, EE 2007, 'A prospective study of fruits, vegetables, and risk of endometrial cancer', American Journal of Epidemiology, vol. 166, no. 8, pp. 902-911. https://doi.org/10.1093/aje/kwm156
McCullough ML, Bandera EV, Patel R, Patel AV, Gansler T, Kushi LH et al. A prospective study of fruits, vegetables, and risk of endometrial cancer. American Journal of Epidemiology. 2007 Oct;166(8):902-911. https://doi.org/10.1093/aje/kwm156
McCullough, Marjorie L. ; Bandera, Elisa V. ; Patel, Roshni ; Patel, Alpa V. ; Gansler, Ted ; Kushi, Lawrence H. ; Thun, Michael J. ; Calle, Eugenia E. / A prospective study of fruits, vegetables, and risk of endometrial cancer. In: American Journal of Epidemiology. 2007 ; Vol. 166, No. 8. pp. 902-911.
@article{98c4de5869dd4e2bbc2cb071a3965f2e,
title = "A prospective study of fruits, vegetables, and risk of endometrial cancer",
abstract = "Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95{\%} confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95{\%} CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95{\%} CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95{\%} CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer.",
keywords = "Cohort studies, Endometrial neoplasms, Fruit, Vegetables",
author = "McCullough, {Marjorie L.} and Bandera, {Elisa V.} and Roshni Patel and Patel, {Alpa V.} and Ted Gansler and Kushi, {Lawrence H.} and Thun, {Michael J.} and Calle, {Eugenia E.}",
year = "2007",
month = "10",
doi = "10.1093/aje/kwm156",
language = "English (US)",
volume = "166",
pages = "902--911",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - A prospective study of fruits, vegetables, and risk of endometrial cancer

AU - McCullough, Marjorie L.

AU - Bandera, Elisa V.

AU - Patel, Roshni

AU - Patel, Alpa V.

AU - Gansler, Ted

AU - Kushi, Lawrence H.

AU - Thun, Michael J.

AU - Calle, Eugenia E.

PY - 2007/10

Y1 - 2007/10

N2 - Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95% confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95% CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95% CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95% CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer.

AB - Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95% confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95% CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95% CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95% CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer.

KW - Cohort studies

KW - Endometrial neoplasms

KW - Fruit

KW - Vegetables

UR - http://www.scopus.com/inward/record.url?scp=34848822522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848822522&partnerID=8YFLogxK

U2 - 10.1093/aje/kwm156

DO - 10.1093/aje/kwm156

M3 - Article

C2 - 17690222

AN - SCOPUS:34848822522

VL - 166

SP - 902

EP - 911

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -