A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings

Tara A Niendam, Carrie E. Bearden, Isabelle M. Rosso, Laura E. Sanchez, Trevor Hadley, Keith H. Nuechterlein, Tyrone D. Cannon

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

Objective: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings. Method: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests. Results: The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest. Conclusions: Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings.

Original languageEnglish (US)
Pages (from-to)2060-2062
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Niendam, T. A., Bearden, C. E., Rosso, I. M., Sanchez, L. E., Hadley, T., Nuechterlein, K. H., & Cannon, T. D. (2003). A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. American Journal of Psychiatry, 160(11), 2060-2062. https://doi.org/10.1176/appi.ajp.160.11.2060