A prospective on farm cohort study investigating the epidemiology and pathophysiology of drunken lamb syndrome

J. W. Angell, G. Jones, D. H. Grove-White, E. Jones, Robert Higgins, A. Otter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Drunken lamb syndrome (DLS) is a fatal disease of unknown aetiology affecting young lambs. In 2011, a prospective on farm cohort study was carried out to investigate the epidemiology and pathophysiology of DLS. Ten cases from a cohort of 1635 crossbred and pure Welsh Mountain lambs were identified as having DLS on the basis of characteristic clinical signs. Renal histopathology demonstrated nephrosis in all 10 cases. Some cases also demonstrated concurrent intestinal pathology. The cases were significantly smaller than the cohort, nine out of the 10 were twins, and they all demonstrated a severe metabolic acidosis characterised by elevated D-lactate. This study demonstrates that D-lactate-probably initiated by the overgrowth of intestinal microorganisms-appears to be the cause of the metabolic acidosis seen in cases of DLS, and to be responsible for the clinical signs seen. It is unclear as to the significance of the nephrosis lesions, and the name 'Lamb Nephrosis' may be misleading. Treatment may be possible using solutions of sodium bicarbonate.

Original languageEnglish (US)
Number of pages1
JournalVeterinary Record
Volume172
Issue number6
DOIs
StatePublished - Feb 9 2013
Externally publishedYes

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pathophysiology
cohort studies
Nephrosis
epidemiology
Epidemiology
lambs
Cohort Studies
farms
nephrosis
Acidosis
Lactic Acid
acidosis
Sodium Bicarbonate
lactates
Names
Welsh Mountain
Pathology
Kidney
sodium bicarbonate
Farms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A prospective on farm cohort study investigating the epidemiology and pathophysiology of drunken lamb syndrome. / Angell, J. W.; Jones, G.; Grove-White, D. H.; Jones, E.; Higgins, Robert; Otter, A.

In: Veterinary Record, Vol. 172, No. 6, 09.02.2013.

Research output: Contribution to journalArticle

Angell, J. W. ; Jones, G. ; Grove-White, D. H. ; Jones, E. ; Higgins, Robert ; Otter, A. / A prospective on farm cohort study investigating the epidemiology and pathophysiology of drunken lamb syndrome. In: Veterinary Record. 2013 ; Vol. 172, No. 6.
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