A prospective cohort study of acute kidney injury in multi-stage ultramarathon runners

The biochemistry in endurance runner study (BIERS)

Grant S. Lipman, Brian J. Krabak, Brandee L Waite, Sarah B. Logan, Anil Menon, Garrett K. Chan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The purpose of the study was to evaluate the prevalence of acute kidney injury (AKI) during a multi-stage ultramarathon foot race. A prospective observational study was taken during the Gobi 2008; Sahara 2008; and Namibia 2009 RacingThePlanet 7-day, 6-stage, 150-mile foot ultramarathons. Blood was analyzed before, and immediately after stage 1 (25 miles), 3 (75 miles), and 5 (140 miles). Creatinine (Cr), glomerular filtration rate (GFR), and incidence of AKI were calculated and defined by RIFLE criteria. Thirty participants (76% male, mean age 40 + 11 years) were enrolled. There were significant declines in GFR after each stage compared with the pre-race baseline (p < 0.001), with the majority of participants (55-80%) incurring AKI. The majority of study participants encountered significant renal impairment; however, no apparent cumulative effect was observed, with resolution of renal function to near baseline levels between stages.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalResearch in Sports Medicine
Volume22
Issue number2
DOIs
StatePublished - Apr 3 2014

Fingerprint

Acute Kidney Injury
Biochemistry
Cohort Studies
Prospective Studies
Glomerular Filtration Rate
Foot
Namibia
Kidney
Northern Africa
Observational Studies
Creatinine
Incidence

Keywords

  • acute kidney injury
  • multi-stage
  • recovery from exercise
  • ultramarathon

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)

Cite this

A prospective cohort study of acute kidney injury in multi-stage ultramarathon runners : The biochemistry in endurance runner study (BIERS). / Lipman, Grant S.; Krabak, Brian J.; Waite, Brandee L; Logan, Sarah B.; Menon, Anil; Chan, Garrett K.

In: Research in Sports Medicine, Vol. 22, No. 2, 03.04.2014, p. 185-192.

Research output: Contribution to journalArticle

Lipman, Grant S. ; Krabak, Brian J. ; Waite, Brandee L ; Logan, Sarah B. ; Menon, Anil ; Chan, Garrett K. / A prospective cohort study of acute kidney injury in multi-stage ultramarathon runners : The biochemistry in endurance runner study (BIERS). In: Research in Sports Medicine. 2014 ; Vol. 22, No. 2. pp. 185-192.
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