Abstract
Purpose. Patients older than 65 years are underrepresented in clinical trials. We conducted a prospective study (SWOG S0316) to determine physicianand patient-perceived barriers to breast cancer clinical trial enrollment for older patients. Methods. Eight geographically diverse SWOG institutions participated. The study assessed patients' and physicians' decisions to enroll in or decline clinical treatment trials, including demographics, trial availability, and eligibility. Patient and physician questionnaires elicited concerns related to treatment, medical status, age, family, and financial or transportation concerns. Results. A total of 1,079 patients were registered and eligible and 909 (84%) returned for follow-up. The major reason for nonaccrual was either trial unavailability or ineligibility (60%). Older patients were less likely to be eligible for trials (65% for age >65 years vs. 78% for age <65 years). If eligible,trialparticipationratesdidnotdiffersignificantlybyage (34%forage>65yearsvs.40%forage<65years).Patients >65yearsmoreoftenwereconcernedaboutsideeffects,had friends opposed to participation, or believed that participation would not benefit other generations. When trials were availableandpatientswereeligible,physiciansdiscussedtrial participation with 76% of patients <65 years versus 58% of patients >65 years of age. For patients >65 years, 11% of physicians indicated age as a reason they did not enroll a patient in a clinical trial. Conclusion. Trial unavailability or patient ineligibility were the major reasons for lack of enrollment in breast cancer clinical trials for patients of all ages in this prospective study. Older patients were less likely to be eligible for trials, but if eligible they participated at similar rates to younger patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1180-1190 |
| Number of pages | 11 |
| Journal | Oncologist |
| Volume | 17 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- Breast cancer
- Clinical trials
- Elderly
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
A prospective analysis of the influence of older age on physician and patient decision-making when considering enrollment in breast cancer clinical trials (SWOG s0316). / Javid, Sara H.; Unger, Joseph M.; Gralow, Julie R.; Moinpour, Carol M.; Wozniak, Antoinette J.; Wendall Goodwin, J.; Lara, Primo N; Williams, Pamela A.; Hutchins, Laura F.; Gotay, Carolyn C.; Albain, Kathy S.
In: Oncologist, Vol. 17, No. 9, 09.2012, p. 1180-1190.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A prospective analysis of the influence of older age on physician and patient decision-making when considering enrollment in breast cancer clinical trials (SWOG s0316)
AU - Javid, Sara H.
AU - Unger, Joseph M.
AU - Gralow, Julie R.
AU - Moinpour, Carol M.
AU - Wozniak, Antoinette J.
AU - Wendall Goodwin, J.
AU - Lara, Primo N
AU - Williams, Pamela A.
AU - Hutchins, Laura F.
AU - Gotay, Carolyn C.
AU - Albain, Kathy S.
PY - 2012/9
Y1 - 2012/9
N2 - Purpose. Patients older than 65 years are underrepresented in clinical trials. We conducted a prospective study (SWOG S0316) to determine physicianand patient-perceived barriers to breast cancer clinical trial enrollment for older patients. Methods. Eight geographically diverse SWOG institutions participated. The study assessed patients' and physicians' decisions to enroll in or decline clinical treatment trials, including demographics, trial availability, and eligibility. Patient and physician questionnaires elicited concerns related to treatment, medical status, age, family, and financial or transportation concerns. Results. A total of 1,079 patients were registered and eligible and 909 (84%) returned for follow-up. The major reason for nonaccrual was either trial unavailability or ineligibility (60%). Older patients were less likely to be eligible for trials (65% for age >65 years vs. 78% for age <65 years). If eligible,trialparticipationratesdidnotdiffersignificantlybyage (34%forage>65yearsvs.40%forage<65years).Patients >65yearsmoreoftenwereconcernedaboutsideeffects,had friends opposed to participation, or believed that participation would not benefit other generations. When trials were availableandpatientswereeligible,physiciansdiscussedtrial participation with 76% of patients <65 years versus 58% of patients >65 years of age. For patients >65 years, 11% of physicians indicated age as a reason they did not enroll a patient in a clinical trial. Conclusion. Trial unavailability or patient ineligibility were the major reasons for lack of enrollment in breast cancer clinical trials for patients of all ages in this prospective study. Older patients were less likely to be eligible for trials, but if eligible they participated at similar rates to younger patients.
AB - Purpose. Patients older than 65 years are underrepresented in clinical trials. We conducted a prospective study (SWOG S0316) to determine physicianand patient-perceived barriers to breast cancer clinical trial enrollment for older patients. Methods. Eight geographically diverse SWOG institutions participated. The study assessed patients' and physicians' decisions to enroll in or decline clinical treatment trials, including demographics, trial availability, and eligibility. Patient and physician questionnaires elicited concerns related to treatment, medical status, age, family, and financial or transportation concerns. Results. A total of 1,079 patients were registered and eligible and 909 (84%) returned for follow-up. The major reason for nonaccrual was either trial unavailability or ineligibility (60%). Older patients were less likely to be eligible for trials (65% for age >65 years vs. 78% for age <65 years). If eligible,trialparticipationratesdidnotdiffersignificantlybyage (34%forage>65yearsvs.40%forage<65years).Patients >65yearsmoreoftenwereconcernedaboutsideeffects,had friends opposed to participation, or believed that participation would not benefit other generations. When trials were availableandpatientswereeligible,physiciansdiscussedtrial participation with 76% of patients <65 years versus 58% of patients >65 years of age. For patients >65 years, 11% of physicians indicated age as a reason they did not enroll a patient in a clinical trial. Conclusion. Trial unavailability or patient ineligibility were the major reasons for lack of enrollment in breast cancer clinical trials for patients of all ages in this prospective study. Older patients were less likely to be eligible for trials, but if eligible they participated at similar rates to younger patients.
KW - Breast cancer
KW - Clinical trials
KW - Elderly
UR - http://www.scopus.com/inward/record.url?scp=84866541186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866541186&partnerID=8YFLogxK
U2 - 10.1634/theoncologist.2011-0384
DO - 10.1634/theoncologist.2011-0384
M3 - Article
C2 - 22723506
AN - SCOPUS:84866541186
VL - 17
SP - 1180
EP - 1190
JO - Oncologist
JF - Oncologist
SN - 1083-7159
IS - 9
ER -