A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice

Jacqueline Crawley, Richard Paylor

Research output: Contribution to journalArticle

438 Citations (Scopus)

Abstract

Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.

Original languageEnglish (US)
Pages (from-to)197-211
Number of pages15
JournalHormones and Behavior
Volume31
Issue number3
DOIs
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Knockout Mice
Transgenic Mice
Phenotype
Neuropsychological Tests
Neurosciences
Aggression
Analgesia
Substance-Related Disorders
Schizophrenia
Research Design
Anxiety
Research Personnel
Learning
Depression

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

@article{0b6f7f95481241ed8d42b0d308841dce,
title = "A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice",
abstract = "Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.",
author = "Jacqueline Crawley and Richard Paylor",
year = "1997",
month = "6",
doi = "10.1006/hbeh.1997.1382",
language = "English (US)",
volume = "31",
pages = "197--211",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice

AU - Crawley, Jacqueline

AU - Paylor, Richard

PY - 1997/6

Y1 - 1997/6

N2 - Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.

AB - Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.

UR - http://www.scopus.com/inward/record.url?scp=0031171578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031171578&partnerID=8YFLogxK

U2 - 10.1006/hbeh.1997.1382

DO - 10.1006/hbeh.1997.1382

M3 - Article

VL - 31

SP - 197

EP - 211

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 3

ER -