A proposed model of naturally occurring osteoarthritis in the domestic rabbit

Boaz Arzi, Erik R Wisner, Daniel J. Huey, Philip H Kass, Jerry Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Osteoarthritis affects one in eight American adults over the age of 25 y and is a leading cause of chronic disability in the US. Translational research to investigate treatments for this naturally occurring joint disease requires an appropriate animal model. The authors conducted a retrospective study to assess the potential of naturally occurring osteoarthritis in the domestic rabbit as a model of the human disease. Analysis of radiographic images showed that the presence and severity of osteoarthritis were significantly influenced by both age and body weight. The most commonly affected joints were the knee and the hip. The findings reported here suggest that the rabbit is an excellent model of spontaneously arising osteoarthritis that may be useful in translational research pertaining to the human disease.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalLab Animal
Volume41
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

osteoarthritis
Osteoarthritis
rabbits
Rabbits
Translational Medical Research
human diseases
joint diseases
Joint Diseases
knees
Knee Joint
hips
retrospective studies
joints (animal)
Hip
Animal Models
Retrospective Studies
animal models
Body Weight
image analysis
body weight

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

A proposed model of naturally occurring osteoarthritis in the domestic rabbit. / Arzi, Boaz; Wisner, Erik R; Huey, Daniel J.; Kass, Philip H; Hu, Jerry; Athanasiou, Kyriacos A.

In: Lab Animal, Vol. 41, No. 1, 01.2012, p. 20-25.

Research output: Contribution to journalArticle

Arzi, Boaz ; Wisner, Erik R ; Huey, Daniel J. ; Kass, Philip H ; Hu, Jerry ; Athanasiou, Kyriacos A. / A proposed model of naturally occurring osteoarthritis in the domestic rabbit. In: Lab Animal. 2012 ; Vol. 41, No. 1. pp. 20-25.
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