Abstract
Central memory T cells (TCM) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human TCM vs effector memory T cells (TEM) from the same donors. In humans, the majority of human TCM were tropic for either skin or gut, and the overall tissue tropism of TCM was comparable to that of TEM TCM were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for TCM in the primary immunosurveillance of peripheral tissues. TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines. TCM injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to TEM-injected mice. In summary, human TCM express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human TCM in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 292-298 |
| Number of pages | 7 |
| Journal | Blood advances |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 13 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
A primary role for human central memory cells in tissue immunosurveillance. / Gehad, Ahmed; Teague, Jessica E.; Matos, Tiago R.; Huang, Victor; Yang, Chao; Watanabe, Rei; O'Malley, John T.; Trimble, Cornelia L.; Kupper, Thomas S.; Clark, Rachael A.
In: Blood advances, Vol. 2, No. 3, 13.02.2018, p. 292-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A primary role for human central memory cells in tissue immunosurveillance
AU - Gehad, Ahmed
AU - Teague, Jessica E.
AU - Matos, Tiago R.
AU - Huang, Victor
AU - Yang, Chao
AU - Watanabe, Rei
AU - O'Malley, John T.
AU - Trimble, Cornelia L.
AU - Kupper, Thomas S.
AU - Clark, Rachael A.
PY - 2018/2/13
Y1 - 2018/2/13
N2 - Central memory T cells (TCM) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human TCM vs effector memory T cells (TEM) from the same donors. In humans, the majority of human TCM were tropic for either skin or gut, and the overall tissue tropism of TCM was comparable to that of TEM TCM were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for TCM in the primary immunosurveillance of peripheral tissues. TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines. TCM injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to TEM-injected mice. In summary, human TCM express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human TCM in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.
AB - Central memory T cells (TCM) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human TCM vs effector memory T cells (TEM) from the same donors. In humans, the majority of human TCM were tropic for either skin or gut, and the overall tissue tropism of TCM was comparable to that of TEM TCM were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for TCM in the primary immunosurveillance of peripheral tissues. TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines. TCM injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to TEM-injected mice. In summary, human TCM express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human TCM in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.
UR - http://www.scopus.com/inward/record.url?scp=85050165403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050165403&partnerID=8YFLogxK
U2 - 10.1182/bloodadvances.2017011346
DO - 10.1182/bloodadvances.2017011346
M3 - Article
C2 - 29437556
AN - SCOPUS:85050165403
VL - 2
SP - 292
EP - 298
JO - Blood advances
JF - Blood advances
SN - 2473-9529
IS - 3
ER -