Abstract
This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Schizophrenia Research |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- (Schizophrenia)
- Family history
- Genetics
- Heterogeneity
- Neuropsychology
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Behavioral Neuroscience
- Neurology
- Psychology(all)
Cite this
A preliminary study of the neuropsychological heterogeneity of familial schizophrenia. / Sautter, Frederic J.; McDermott, Barbara E; Cornwell, John; Johnson, Janet; Borges, Alicia; Wilson, Alexander F.; Vasterling, Jennifer J.; Foundas, Anne L.
In: Schizophrenia Research, Vol. 18, No. 1, 1995, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A preliminary study of the neuropsychological heterogeneity of familial schizophrenia
AU - Sautter, Frederic J.
AU - McDermott, Barbara E
AU - Cornwell, John
AU - Johnson, Janet
AU - Borges, Alicia
AU - Wilson, Alexander F.
AU - Vasterling, Jennifer J.
AU - Foundas, Anne L.
PY - 1995
Y1 - 1995
N2 - This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.
AB - This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.
KW - (Schizophrenia)
KW - Family history
KW - Genetics
KW - Heterogeneity
KW - Neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=0030021168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030021168&partnerID=8YFLogxK
U2 - 10.1016/0920-9964(95)00015-1
DO - 10.1016/0920-9964(95)00015-1
M3 - Article
C2 - 8929755
AN - SCOPUS:0030021168
VL - 18
SP - 1
EP - 7
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -