A preliminary study of the neuropsychological heterogeneity of familial schizophrenia

Frederic J. Sautter, Barbara E McDermott, John Cornwell, Janet Johnson, Alicia Borges, Alexander F. Wilson, Jennifer J. Vasterling, Anne L. Foundas

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalSchizophrenia Research
Volume18
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

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Schizophrenia
Frontal Lobe
Cluster Analysis

Keywords

  • (Schizophrenia)
  • Family history
  • Genetics
  • Heterogeneity
  • Neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Sautter, F. J., McDermott, B. E., Cornwell, J., Johnson, J., Borges, A., Wilson, A. F., ... Foundas, A. L. (1995). A preliminary study of the neuropsychological heterogeneity of familial schizophrenia. Schizophrenia Research, 18(1), 1-7. https://doi.org/10.1016/0920-9964(95)00015-1

A preliminary study of the neuropsychological heterogeneity of familial schizophrenia. / Sautter, Frederic J.; McDermott, Barbara E; Cornwell, John; Johnson, Janet; Borges, Alicia; Wilson, Alexander F.; Vasterling, Jennifer J.; Foundas, Anne L.

In: Schizophrenia Research, Vol. 18, No. 1, 1995, p. 1-7.

Research output: Contribution to journalArticle

Sautter, FJ, McDermott, BE, Cornwell, J, Johnson, J, Borges, A, Wilson, AF, Vasterling, JJ & Foundas, AL 1995, 'A preliminary study of the neuropsychological heterogeneity of familial schizophrenia', Schizophrenia Research, vol. 18, no. 1, pp. 1-7. https://doi.org/10.1016/0920-9964(95)00015-1
Sautter, Frederic J. ; McDermott, Barbara E ; Cornwell, John ; Johnson, Janet ; Borges, Alicia ; Wilson, Alexander F. ; Vasterling, Jennifer J. ; Foundas, Anne L. / A preliminary study of the neuropsychological heterogeneity of familial schizophrenia. In: Schizophrenia Research. 1995 ; Vol. 18, No. 1. pp. 1-7.
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