A preliminary study of the neuropsychological heterogeneity of familial schizophrenia

Frederic J. Sautter, Barbara E McDermott, John Cornwell, Janet Johnson, Alicia Borges, Alexander F. Wilson, Jennifer J. Vasterling, Anne L. Foundas

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalSchizophrenia Research
Issue number1
StatePublished - 1995
Externally publishedYes


  • (Schizophrenia)
  • Family history
  • Genetics
  • Heterogeneity
  • Neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)


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