A preliminary study of screening for risk of autism in children with fragile X syndrome: Testing two risk cut-offs for the Checklist for Autism in Toddlers

Douglas J. Scambler, S. L. Hepburn, Randi J Hagerman, Sally J Rogers

Research output: Contribution to journalArticle

6 Scopus citations


Objective: Risk criteria for the Checklist for Autism in Toddlers (CHAT) and modified risk criteria (i.e. the Denver Criteria) were compared in a group of children with fragile X syndrome (FXS) and autism. Method: Participants were 17 children aged 2-4 years with DNA confirmation of FXS. Four children had autism and 13 children did not. Results: Preliminary findings regarding the sensitivity and specificity of the CHAT for detecting risk for autism in children with FXS are as follows: using the original CHAT risk criteria, sensitivity and specificity were 50% and 100%, respectively; and using the Denver Criteria, sensitivity and specificity were 75% and 92%, respectively. Conclusions: The CHAT and the Denver Criteria resulted in preliminary findings suggesting high levels of sensitivity to autism in children with FXS.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalJournal of Intellectual Disability Research
Issue number4
StatePublished - Apr 2007



  • Autism
  • FragileX syndrome
  • Screening

ASJC Scopus subject areas

  • Genetics
  • Health Professions(all)
  • Rehabilitation
  • Genetics(clinical)
  • Education
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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