A practical guide of the southwest oncology group to measure malignant pleural mesothelioma tumors by RECIST and modified RECIST criteria

Anne S. Tsao, Linda Garland, Mary Redman, Kemp Kernstine, David R Gandara, Edith M. Marom

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Malignant pleural mesothelioma (MPM) is difficult to measure radiographically due to the nonradial and variable pattern of growth and response to therapy. Inaccurate and inconsistent tumor measurements often compromise results from clinical trials that are dependent on identifying response rate and progression-free survival. In this article, we sought to provide a practical guide through the Southwest Oncology Group on how to measure MPM by the updated RECIST version 1.1 and by modified RECIST. We hope that these steps will provide a simple means by which computed tomography measurements can be consistently performed, minimizing intra- and interobserver variability. With this consistency, we may be able to better estimate the prognosis and response to therapy. With greater utilization, we will be able to better understand the biology of MPM.

Original languageEnglish (US)
Pages (from-to)598-601
Number of pages4
JournalJournal of Thoracic Oncology
Volume6
Issue number3
DOIs
StatePublished - Mar 2011

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Keywords

  • Measurement
  • Mesothelioma
  • Modified RECIST
  • RECIST

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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