A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle

Jonathan Widdicombe, A. F. Brading

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Smooth muscles actively accumulate Cl. Abolition of the transmembrane Na gradient has been shown to lead to a passive distribution of Cl. This suggested to us that Na and Cl may move together across the smooth muscle cell membrane, Cl accumulation resulting due to [Na]i being less than [Na]o. In favour of this view are the findings that Cl uptake is reduced in Na-free medium, Na uptake is reduced in Cl-free medium, reducing [Cl]i reduces Na efflux, and increasing [Na]i increases Cl efflux.

Original languageEnglish (US)
Pages (from-to)35-37
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume386
Issue number1
DOIs
StatePublished - Jul 1980
Externally publishedYes

Keywords

  • Cl transport
  • Smooth muscle

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle'. Together they form a unique fingerprint.

Cite this