A population of murine γδ T cells that recognize an inducible MHC class Ib molecule

Michael P. Crowley, Aude M. Fahrer, Nicole Baumgarth, Johannes Hampl, Ines Gutgemann, Luc Teyton, Yueh Hsiu Chien

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Abstract

Although γδ T cells are implicated in regulating immune responses, γδ T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the γδ T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory γδ T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for γδ T cell activation.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
JournalScience
Volume287
Issue number5451
DOIs
StatePublished - 2000
Externally publishedYes

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Cite this

Crowley, M. P., Fahrer, A. M., Baumgarth, N., Hampl, J., Gutgemann, I., Teyton, L., & Chien, Y. H. (2000). A population of murine γδ T cells that recognize an inducible MHC class Ib molecule. Science, 287(5451), 314-316. https://doi.org/10.1126/science.287.5451.314