A polytropic caprine arthritis encephalitis virus promoter isolated from multiple tissues from a sheep with multisystemic lentivirus-associated inflammatory disease

Adeyemi O. Adedeji, Bradd Barr, Esperanza Gomez-Lucia, Brian G Murphy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Caprine arthritis encephalitis virus (CAEV) is a lentivirus that infects both goats and sheep and is closely related to maedi-visna virus that infects sheep; collectively, these viruses are known as small ruminant lentiviruses (SRLV). Infection of goats and sheep with SRLV typically results in discrete inflammatory diseases which include arthritis, mastitis, pneumonia or encephalomyelitis. SRLV-infected animals concurrently demonstrating lentivirus-associated lesions in tissues of lung, mammary gland, joint synovium and the central nervous system are either very rare or have not been reported. Here we describe a novel CAEV promoter isolated from a sheep with multisystemic lentivirus-associated inflammatory disease including interstitial pneumonia, mastitis, polyarthritis and leukomyelitis. A single, novel SRLV promoter was cloned and sequenced from five different anatomical locations (brain stem, spinal cord, lung, mammary gland and carpal joint synovium), all of which demonstrated lesions characteristic of lentivirus associated inflammation. This SRLV promoter isolate was found to be closely related to CAEV promoters isolated from goats in northern California and other parts of the world. The promoter was denoted CAEV-ovine-MS (multisystemic disease); the stability of the transcription factor binding sites within the U3 promoter sequence are discussed.

Original languageEnglish (US)
Pages (from-to)2005-2018
Number of pages14
JournalViruses
Volume5
Issue number8
DOIs
StatePublished - Aug 15 2013

Fingerprint

Caprine Arthritis-Encephalitis Viruses
Lentivirus
Sheep
Ruminants
Goats
Synovial Membrane
Mastitis
Human Mammary Glands
Arthritis
Visna-maedi virus
Wrist Joint
Encephalomyelitis
Lung
Interstitial Lung Diseases
Brain Stem
Spinal Cord
Pneumonia
Transcription Factors
Central Nervous System
Joints

Keywords

  • CAEV
  • Multisystemic
  • Promoter
  • SRLV

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

A polytropic caprine arthritis encephalitis virus promoter isolated from multiple tissues from a sheep with multisystemic lentivirus-associated inflammatory disease. / Adedeji, Adeyemi O.; Barr, Bradd; Gomez-Lucia, Esperanza; Murphy, Brian G.

In: Viruses, Vol. 5, No. 8, 15.08.2013, p. 2005-2018.

Research output: Contribution to journalArticle

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