A polymer-supported C2-symmetric chiral auxiliary: Preparation of non-racemic 3,5-disubstituted-γ-butyrolactones

Hong sik Moon, Neil E. Schore, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


A polymer-bound "C2-symmetric" pyrrolidine-based auxiliary is reported and shown to serve an effective control element for a three-step process consisting of N-acylation, Cα-alkylation, and subsequent iodolactonization to deliver optically active 3,5-disubstituted-γ-butyrolactone.

Original languageEnglish (US)
Pages (from-to)8915-8918
Number of pages4
JournalTetrahedron Letters
Issue number48
StatePublished - Nov 28 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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