A placebo-controlled, double-blind crossover study of naltrexone hydrochloride in outpatients with normal weight bulimia

J. E. Mitchell, G. Christenson, J. Jennings, M. Huber, B. Thomas, Claire Pomeroy, J. Morley

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

The endogenous opioid system plays an important role in the control of feeding behavior. Previous research has shown that antagonism of endogenous opioids will suppress feeding in certain models in both human and infrahuman species. In the current study, 16 normal-weight bulimic women were treated with low-dose naltrexone, the long-acting, orally active narcotic antagonist, and placebo in a crossover design. The use of the active drug was not associated with a clinically significant reduction in binge eating or vomiting episodes. Suggestions for further research in this area are offered.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume9
Issue number2
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Mitchell, J. E., Christenson, G., Jennings, J., Huber, M., Thomas, B., Pomeroy, C., & Morley, J. (1989). A placebo-controlled, double-blind crossover study of naltrexone hydrochloride in outpatients with normal weight bulimia. Journal of Clinical Psychopharmacology, 9(2), 94-97.