A pilot study on the effi cacy of continuous positive airway pressure on the manifestations of ménière's disease in patients with concomitant obstructive sleep apnea syndrome

Meiho Nakayama, Ayako Masuda, Kayoko Bhardwaj Ando, Sachie Arima, Kayoko Kabaya, Akira Inagaki, Yoshihisa Nakamura, Motohiko Suzuki, Hilary A Brodie, Rodney C Diaz, Shingo Murakami

Research output: Contribution to journalArticle

10 Scopus citations


Objective: To evaluate the effect of continuous positive airway pressure (CPAP) therapy on Ménière's disease patients with concomitant obstructive sleep apnea syndrome (OSAS), since recent reports suggest OSAS may cause dysfunction of the vestibular system. Study Design: Prospective study using CPAP administered to patients diagnosed with "Defi nite Ménière's disease" according to the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery and combined with OSAS. Setting: University hospital. Methods: Twenty consecutive patients, 14 male and 6 female with active, unilateral, cochleovestibular Ménière's disease refractory to medical management who also had concurrent OSAS as defi ned by International Classifi cation of Sleep Disorders, Second Edition were selected to undergo solitary CPAP therapy. Audiometric testing, caloric testing, and DHI survey were conducted before and after CPAP therapy and compared to assess effectiveness of CPAP therapy as utilized for treatment of Ménière's disease. Results: Although caloric testing did not show signifi cant difference, audiometric testing and results of dizziness handicap inventory were signifi cantly improved (p <0.05) after CPAP therapy only, without standard treatment for Ménière's disease. Conclusions: Recent reports have suggested that OSAS may cause dysfunction of the vestibular system. We investigated whether standard therapy for OSAS would be of benefi t in the management of vertigo and hearing loss in Ménière's disease patients. Our study cohort demonstrated signifi cant improvement in both DHI and audiometric testing following solitary CPAP therapy for OSAS. Solitary CPAP therapy may become a new effective treatment strategy for Ménière's disease patients with OSAS, not just only for control of dizziness and vertigo but also for potential benefi t of hearing.

Original languageEnglish (US)
Pages (from-to)1101-1107
Number of pages7
JournalJournal of Clinical Sleep Medicine
Issue number10
StatePublished - 2015



  • Audiogram
  • Caloric test
  • CPAP
  • DHI
  • Ménière's disease
  • OSAS
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

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