A pilot study of mifepristone and misoprostol administered at the same time for abortion in women with gestation from 50 to 63 days

Courtney A. Schreiber, Mitchell D Creinin, Bryna Harwood, Amitasrigowri S. Murthy

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Introduction: In the interest of decreasing the amount of time it takes to achieve a medical abortion, we performed a pilot study to evaluate the simultaneous administration of mifepristone and vaginal misoprostol for women with gestation from 50 to 63 days. Materials and Methods: Forty women were enrolled with undesired pregnancies from 50 to 56 days' gestation (group 1) and 40 from 57 to 63 days' gestation (group 2). All women used misoprostol 800 μg vaginally immediately after having swallowed the 200 mg mifepristone tablet. Follow-up evaluations with transvaginal ultrasonography occurred at 24 h and 2 weeks after treatment. Results: The 24-h expulsion rates were 88% (95% CI, 77-98) and 83% (95% CI, 7-94) in groups 1 and 2, respectively. The complete abortion rates at 2 weeks were 93% (95% CI, 84-100) and 90% (95% CI, 81-99), respectively. Discussion: Simultaneous administration of oral mifepristone and vaginal misoprostol provides 24-h expulsion rates in women with gestation from 50 to 63 days, comparable to those reported in the medical literature for standard treatment regimens. Further study of this regimen in a large randomized trial is warranted.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalContraception
Volume71
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Abortion
  • Medical abortion
  • Mifepristone
  • Misoprostol

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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