Abstract
Hypothesis: Simultaneous administration of mifepristone and misoprostol for medical abortion in women up to 49 days gestation will result in complete abortion in 90% of women within 24 h of treatment. Materials and Methods: Forty women with pregnancies up to 49 days gestation inserted 800 μg vaginal misoprostol in our office immediately after taking mifepristone 200 mg orally. Follow-up visits, which included vaginal ultrasonography, occurred 24±1 h and 2 weeks after treatment. If a gestational sac was still present at the first follow-up visit, the misoprostol dose was repeated. Suction abortion was performed for a viable gestation at the second follow-up visit, presence of a nonviable gestation within 5 weeks of treatment and when clinically indicated. Results: Expulsion occurred in 36/40 (90%, 95% CI 80-99) and 39/40 (98%, 95% CI 93-100) women by the first and second follow-up visits, respectively. One woman who had initially expelled the gestational sac after a single dose of misoprostol later required a suction curettage for an incomplete abortion. Conclusion: Simultaneous administration of mifepristone and vaginal misoprostol is a promising regimen for medical abortion up to 49 days gestation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 333-336 |
| Number of pages | 4 |
| Journal | Contraception |
| Volume | 71 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2005 |
| Externally published | Yes |
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Keywords
- Abortion
- Medical abortion
- Mifepristone
- Misoprostol
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation. / Murthy, Amitasrigowri S.; Creinin, Mitchell D; Harwood, Bryna; Schreiber, Courtney.
In: Contraception, Vol. 71, No. 5, 05.2005, p. 333-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation
AU - Murthy, Amitasrigowri S.
AU - Creinin, Mitchell D
AU - Harwood, Bryna
AU - Schreiber, Courtney
PY - 2005/5
Y1 - 2005/5
N2 - Hypothesis: Simultaneous administration of mifepristone and misoprostol for medical abortion in women up to 49 days gestation will result in complete abortion in 90% of women within 24 h of treatment. Materials and Methods: Forty women with pregnancies up to 49 days gestation inserted 800 μg vaginal misoprostol in our office immediately after taking mifepristone 200 mg orally. Follow-up visits, which included vaginal ultrasonography, occurred 24±1 h and 2 weeks after treatment. If a gestational sac was still present at the first follow-up visit, the misoprostol dose was repeated. Suction abortion was performed for a viable gestation at the second follow-up visit, presence of a nonviable gestation within 5 weeks of treatment and when clinically indicated. Results: Expulsion occurred in 36/40 (90%, 95% CI 80-99) and 39/40 (98%, 95% CI 93-100) women by the first and second follow-up visits, respectively. One woman who had initially expelled the gestational sac after a single dose of misoprostol later required a suction curettage for an incomplete abortion. Conclusion: Simultaneous administration of mifepristone and vaginal misoprostol is a promising regimen for medical abortion up to 49 days gestation.
AB - Hypothesis: Simultaneous administration of mifepristone and misoprostol for medical abortion in women up to 49 days gestation will result in complete abortion in 90% of women within 24 h of treatment. Materials and Methods: Forty women with pregnancies up to 49 days gestation inserted 800 μg vaginal misoprostol in our office immediately after taking mifepristone 200 mg orally. Follow-up visits, which included vaginal ultrasonography, occurred 24±1 h and 2 weeks after treatment. If a gestational sac was still present at the first follow-up visit, the misoprostol dose was repeated. Suction abortion was performed for a viable gestation at the second follow-up visit, presence of a nonviable gestation within 5 weeks of treatment and when clinically indicated. Results: Expulsion occurred in 36/40 (90%, 95% CI 80-99) and 39/40 (98%, 95% CI 93-100) women by the first and second follow-up visits, respectively. One woman who had initially expelled the gestational sac after a single dose of misoprostol later required a suction curettage for an incomplete abortion. Conclusion: Simultaneous administration of mifepristone and vaginal misoprostol is a promising regimen for medical abortion up to 49 days gestation.
KW - Abortion
KW - Medical abortion
KW - Mifepristone
KW - Misoprostol
UR - http://www.scopus.com/inward/record.url?scp=18044386575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18044386575&partnerID=8YFLogxK
U2 - 10.1016/j.contraception.2004.10.006
DO - 10.1016/j.contraception.2004.10.006
M3 - Article
C2 - 15854632
AN - SCOPUS:18044386575
VL - 71
SP - 333
EP - 336
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 5
ER -