A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann, Antje K. Heinrich, Alexander O. Brachmann, Christophe Morisseau, Krishnendu Mukherjee, Ángel M. Casanova-Torres, Frederic Strobl, David Kleinhans, Sebastian Kinski, Katharina Schultz, Michael L. Beeton, Marcel Kaiser, Ya Yun Chu, Long Phan Ke, Aunchalee Thanwisai, Kenan A J Bozhüyük, Narisara Chantratita, Friedrich Götz, Nick R. Waterfield, Andreas VilcinskasErnst H K Stelzer, Heidi Goodrich-Blair, Bruce D. Hammock, Helge B. Bode

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Original languageEnglish (US)
Pages (from-to)766-771
Number of pages6
JournalChemBioChem
Volume16
Issue number5
DOIs
StatePublished - Mar 23 2015

Keywords

  • biosynthesis
  • entomopathogenic bacteria
  • juvenile hormone epoxide hydrolase inhibitor
  • natural products
  • Photorhabdus

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y. Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., ... Bode, H. B. (2015). A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, 16(5), 766-771. https://doi.org/10.1002/cbic.201402650