A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Friederike I. Nollmann, Antje K. Heinrich, Alexander O. Brachmann, Christophe Morisseau, Krishnendu Mukherjee, Ángel M. Casanova-Torres, Frederic Strobl, David Kleinhans, Sebastian Kinski, Katharina Schultz, Michael L. Beeton, Marcel Kaiser, Ya Yun Chu, Long Phan Ke, Aunchalee Thanwisai, Kenan A J Bozhüyük, Narisara Chantratita, Friedrich Götz, Nick R. Waterfield, Andreas VilcinskasErnst H K Stelzer, Heidi Goodrich-Blair, Bruce D. Hammock, Helge B. Bode

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Original languageEnglish (US)
Pages (from-to)766-771
Number of pages6
JournalChemBioChem
Volume16
Issue number5
DOIs
StatePublished - Mar 23 2015

Fingerprint

Photorhabdus
Insect Hormones
Biological Products
Biosynthesis
Growth and Development
Virulence
Insects
Urea
Bacteria
Enzymes
juvenile hormone epoxide hydrolase

Keywords

  • biosynthesis
  • entomopathogenic bacteria
  • juvenile hormone epoxide hydrolase inhibitor
  • natural products
  • Photorhabdus

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., ... Bode, H. B. (2015). A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, 16(5), 766-771. https://doi.org/10.1002/cbic.201402650

A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. / Nollmann, Friederike I.; Heinrich, Antje K.; Brachmann, Alexander O.; Morisseau, Christophe; Mukherjee, Krishnendu; Casanova-Torres, Ángel M.; Strobl, Frederic; Kleinhans, David; Kinski, Sebastian; Schultz, Katharina; Beeton, Michael L.; Kaiser, Marcel; Chu, Ya Yun; Phan Ke, Long; Thanwisai, Aunchalee; Bozhüyük, Kenan A J; Chantratita, Narisara; Götz, Friedrich; Waterfield, Nick R.; Vilcinskas, Andreas; Stelzer, Ernst H K; Goodrich-Blair, Heidi; Hammock, Bruce D.; Bode, Helge B.

In: ChemBioChem, Vol. 16, No. 5, 23.03.2015, p. 766-771.

Research output: Contribution to journalArticle

Nollmann, FI, Heinrich, AK, Brachmann, AO, Morisseau, C, Mukherjee, K, Casanova-Torres, ÁM, Strobl, F, Kleinhans, D, Kinski, S, Schultz, K, Beeton, ML, Kaiser, M, Chu, YY, Phan Ke, L, Thanwisai, A, Bozhüyük, KAJ, Chantratita, N, Götz, F, Waterfield, NR, Vilcinskas, A, Stelzer, EHK, Goodrich-Blair, H, Hammock, BD & Bode, HB 2015, 'A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase', ChemBioChem, vol. 16, no. 5, pp. 766-771. https://doi.org/10.1002/cbic.201402650
Nollmann FI, Heinrich AK, Brachmann AO, Morisseau C, Mukherjee K, Casanova-Torres ÁM et al. A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem. 2015 Mar 23;16(5):766-771. https://doi.org/10.1002/cbic.201402650
Nollmann, Friederike I. ; Heinrich, Antje K. ; Brachmann, Alexander O. ; Morisseau, Christophe ; Mukherjee, Krishnendu ; Casanova-Torres, Ángel M. ; Strobl, Frederic ; Kleinhans, David ; Kinski, Sebastian ; Schultz, Katharina ; Beeton, Michael L. ; Kaiser, Marcel ; Chu, Ya Yun ; Phan Ke, Long ; Thanwisai, Aunchalee ; Bozhüyük, Kenan A J ; Chantratita, Narisara ; Götz, Friedrich ; Waterfield, Nick R. ; Vilcinskas, Andreas ; Stelzer, Ernst H K ; Goodrich-Blair, Heidi ; Hammock, Bruce D. ; Bode, Helge B. / A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. In: ChemBioChem. 2015 ; Vol. 16, No. 5. pp. 766-771.
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