A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival

Amir Rattner, Philip M. Smallwood, John Williams, Carol Cooke, Andrey Savchenko, Arkady Lyubarsky, Edward N Pugh Jr, Jeremy Nathans

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.

Original languageEnglish (US)
Pages (from-to)775-786
Number of pages12
JournalNeuron
Volume32
Issue number5
DOIs
StatePublished - Dec 6 2001
Externally publishedYes

Fingerprint

Vertebrate Photoreceptor Cells
Cadherins
Light Signal Transduction
Photoreceptor Cells
Protein Transport
Retina
Proteins
Complementary DNA
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rattner, A., Smallwood, P. M., Williams, J., Cooke, C., Savchenko, A., Lyubarsky, A., ... Nathans, J. (2001). A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron, 32(5), 775-786. https://doi.org/10.1016/S0896-6273(01)00531-1

A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. / Rattner, Amir; Smallwood, Philip M.; Williams, John; Cooke, Carol; Savchenko, Andrey; Lyubarsky, Arkady; Pugh Jr, Edward N; Nathans, Jeremy.

In: Neuron, Vol. 32, No. 5, 06.12.2001, p. 775-786.

Research output: Contribution to journalArticle

Rattner, A, Smallwood, PM, Williams, J, Cooke, C, Savchenko, A, Lyubarsky, A, Pugh Jr, EN & Nathans, J 2001, 'A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival', Neuron, vol. 32, no. 5, pp. 775-786. https://doi.org/10.1016/S0896-6273(01)00531-1
Rattner, Amir ; Smallwood, Philip M. ; Williams, John ; Cooke, Carol ; Savchenko, Andrey ; Lyubarsky, Arkady ; Pugh Jr, Edward N ; Nathans, Jeremy. / A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. In: Neuron. 2001 ; Vol. 32, No. 5. pp. 775-786.
@article{1bd681289ba14054aaafe314bd3568d3,
title = "A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival",
abstract = "A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.",
author = "Amir Rattner and Smallwood, {Philip M.} and John Williams and Carol Cooke and Andrey Savchenko and Arkady Lyubarsky and {Pugh Jr}, {Edward N} and Jeremy Nathans",
year = "2001",
month = "12",
day = "6",
doi = "10.1016/S0896-6273(01)00531-1",
language = "English (US)",
volume = "32",
pages = "775--786",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival

AU - Rattner, Amir

AU - Smallwood, Philip M.

AU - Williams, John

AU - Cooke, Carol

AU - Savchenko, Andrey

AU - Lyubarsky, Arkady

AU - Pugh Jr, Edward N

AU - Nathans, Jeremy

PY - 2001/12/6

Y1 - 2001/12/6

N2 - A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.

AB - A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.

UR - http://www.scopus.com/inward/record.url?scp=0035819066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035819066&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(01)00531-1

DO - 10.1016/S0896-6273(01)00531-1

M3 - Article

C2 - 11738025

AN - SCOPUS:0035819066

VL - 32

SP - 775

EP - 786

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -