Abstract
A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 775-786 |
| Number of pages | 12 |
| Journal | Neuron |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| State | Published - Dec 6 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. / Rattner, Amir; Smallwood, Philip M.; Williams, John; Cooke, Carol; Savchenko, Andrey; Lyubarsky, Arkady; Pugh Jr, Edward N; Nathans, Jeremy.
In: Neuron, Vol. 32, No. 5, 06.12.2001, p. 775-786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival
AU - Rattner, Amir
AU - Smallwood, Philip M.
AU - Williams, John
AU - Cooke, Carol
AU - Savchenko, Andrey
AU - Lyubarsky, Arkady
AU - Pugh Jr, Edward N
AU - Nathans, Jeremy
PY - 2001/12/6
Y1 - 2001/12/6
N2 - A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.
AB - A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD-/- mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD-/- mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.
UR - http://www.scopus.com/inward/record.url?scp=0035819066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035819066&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(01)00531-1
DO - 10.1016/S0896-6273(01)00531-1
M3 - Article
C2 - 11738025
AN - SCOPUS:0035819066
VL - 32
SP - 775
EP - 786
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -