A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

Chikako Komeda, Atsushi Ikeda, Jun Ichi Kikuchi, Norihiro Ishida-Kitagawa, Hisashi Tatebe, Kazuhiro Shiozaki, Motofusa Akiyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.

Original languageEnglish (US)
Pages (from-to)2567-2570
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number16
DOIs
StatePublished - Apr 28 2013
Externally publishedYes

Fingerprint

Singlet Oxygen
Drug Carriers
Photosensitizing Agents
Liposomes
lipids
glycols
polyethylenes
cleavage
drugs
Fullerenes
Lipids
cholesterol
oxygen
linkages
fullerenes
ethers
Cholesterol
Derivatives
coatings
Coatings

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Komeda, C., Ikeda, A., Kikuchi, J. I., Ishida-Kitagawa, N., Tatebe, H., Shiozaki, K., & Akiyama, M. (2013). A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. Organic and Biomolecular Chemistry, 11(16), 2567-2570. https://doi.org/10.1039/c2ob27199k

A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. / Komeda, Chikako; Ikeda, Atsushi; Kikuchi, Jun Ichi; Ishida-Kitagawa, Norihiro; Tatebe, Hisashi; Shiozaki, Kazuhiro; Akiyama, Motofusa.

In: Organic and Biomolecular Chemistry, Vol. 11, No. 16, 28.04.2013, p. 2567-2570.

Research output: Contribution to journalArticle

Komeda, C, Ikeda, A, Kikuchi, JI, Ishida-Kitagawa, N, Tatebe, H, Shiozaki, K & Akiyama, M 2013, 'A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen', Organic and Biomolecular Chemistry, vol. 11, no. 16, pp. 2567-2570. https://doi.org/10.1039/c2ob27199k
Komeda, Chikako ; Ikeda, Atsushi ; Kikuchi, Jun Ichi ; Ishida-Kitagawa, Norihiro ; Tatebe, Hisashi ; Shiozaki, Kazuhiro ; Akiyama, Motofusa. / A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. In: Organic and Biomolecular Chemistry. 2013 ; Vol. 11, No. 16. pp. 2567-2570.
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