A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

Chikako Komeda, Atsushi Ikeda, Jun Ichi Kikuchi, Norihiro Ishida-Kitagawa, Hisashi Tatebe, Kazuhiro Shiozaki, Motofusa Akiyama

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.

Original languageEnglish (US)
Pages (from-to)2567-2570
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number16
DOIs
StatePublished - Apr 28 2013
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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  • Cite this

    Komeda, C., Ikeda, A., Kikuchi, J. I., Ishida-Kitagawa, N., Tatebe, H., Shiozaki, K., & Akiyama, M. (2013). A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. Organic and Biomolecular Chemistry, 11(16), 2567-2570. https://doi.org/10.1039/c2ob27199k