Abstract
Paclitaxel and carboplatin is widely used in the treatment of patients with advanced non-small cell lung cancer (NSCLC); however, median survival remains <1 year. One strategy to improve survival is to add a third active drug with a differing mechanism of action. Gemcitabine is a novel antimetabolite with considerable activity in NSCLC. The primary objective of this Phase I/II study was to determine the maximally tolerated dose of gemcitabine administered with fixed doses of paclitaxel and carboplatin in untreated patients with advanced NSCLC.
Original language | English (US) |
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Pages (from-to) | 3474-3479 |
Number of pages | 6 |
Journal | Clinical Cancer Research |
Volume | 6 |
Issue number | 9 |
State | Published - 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research
- Oncology