A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy

L. Fredrik Jarskog; Martin T. Lowy; Richard A. Grove; Richard S E Keefe; Joseph P. Horrigan; M. Patricia Ball; Alan Breier; Robert W. Buchanan; Cameron S Carter; John G. Csernansky; Donald C. Goff; Michael F. Green; Joshua T. Kantrowitz; Matcheri S. Keshavan; Marc Laurelle; Jeffrey A. Lieberman; Stephen R. Marder; Paul Maruff; Robert P. McMahon; Larry J. Seidman; Margaret A. Peykamian

doi:10.1016/j.schres.2015.01.041

A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy

L. Fredrik Jarskog, Martin T. Lowy, Richard A. Grove, Richard S E Keefe, Joseph P. Horrigan, M. Patricia Ball, Alan Breier, Robert W. Buchanan, Cameron S Carter, John G. Csernansky, Donald C. Goff, Michael F. Green, Joshua T. Kantrowitz, Matcheri S. Keshavan, Marc Laurelle, Jeffrey A. Lieberman, Stephen R. Marder, Paul Maruff, Robert P. McMahon, Larry J. SeidmanMargaret A. Peykamian

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H<inf>3</inf> receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7weeks (4weeks titration). GSK239512 was associated with a small positive effect size (ES) on the CogState Schizophrenia Battery (CSSB) Composite Score (ES=0.29, CI=-0.40, 0.99) relative to placebo (primary endpoint). GSK239512's ES on CSSB domains were generally positive or neutral except Processing Speed, which favored placebo (ES=-0.46). Effects on the MATRICS Consensus Cognitive Battery were mostly neutral or favored placebo. GSK239512 was generally well tolerated with an adverse event profile consistent with the known class pharmacology. There was no evidence of overall beneficial effects of GSK239512 for CIAS in this population.

Original language	English (US)
Pages (from-to)	136-142
Number of pages	7
Journal	Schizophrenia Research
Volume	164
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2015.01.041
State	Published - May 1 2015

Keywords

Cognition
CogState Schizophrenia Battery
GSK239512
Histamine H<inf>3</inf> antagonist
MATRICS Consensus Cognition Battery
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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Jarskog, L. F., Lowy, M. T., Grove, R. A., Keefe, R. S. E., Horrigan, J. P., Ball, M. P., Breier, A., Buchanan, R. W., Carter, C. S., Csernansky, J. G., Goff, D. C., Green, M. F., Kantrowitz, J. T., Keshavan, M. S., Laurelle, M., Lieberman, J. A., Marder, S. R., Maruff, P., McMahon, R. P., ... Peykamian, M. A. (2015). A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy. Schizophrenia Research, 164(1-3), 136-142. https://doi.org/10.1016/j.schres.2015.01.041

A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy. / Jarskog, L. Fredrik; Lowy, Martin T.; Grove, Richard A.; Keefe, Richard S E; Horrigan, Joseph P.; Ball, M. Patricia; Breier, Alan; Buchanan, Robert W.; Carter, Cameron S; Csernansky, John G.; Goff, Donald C.; Green, Michael F.; Kantrowitz, Joshua T.; Keshavan, Matcheri S.; Laurelle, Marc; Lieberman, Jeffrey A.; Marder, Stephen R.; Maruff, Paul; McMahon, Robert P.; Seidman, Larry J.; Peykamian, Margaret A.

In: Schizophrenia Research, Vol. 164, No. 1-3, 01.05.2015, p. 136-142.

Research output: Contribution to journal › Article › peer-review

Jarskog, LF, Lowy, MT, Grove, RA, Keefe, RSE, Horrigan, JP, Ball, MP, Breier, A, Buchanan, RW, Carter, CS, Csernansky, JG, Goff, DC, Green, MF, Kantrowitz, JT, Keshavan, MS, Laurelle, M, Lieberman, JA, Marder, SR, Maruff, P, McMahon, RP, Seidman, LJ & Peykamian, MA 2015, 'A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy', Schizophrenia Research, vol. 164, no. 1-3, pp. 136-142. https://doi.org/10.1016/j.schres.2015.01.041

Jarskog, L. Fredrik ; Lowy, Martin T. ; Grove, Richard A. ; Keefe, Richard S E ; Horrigan, Joseph P. ; Ball, M. Patricia ; Breier, Alan ; Buchanan, Robert W. ; Carter, Cameron S ; Csernansky, John G. ; Goff, Donald C. ; Green, Michael F. ; Kantrowitz, Joshua T. ; Keshavan, Matcheri S. ; Laurelle, Marc ; Lieberman, Jeffrey A. ; Marder, Stephen R. ; Maruff, Paul ; McMahon, Robert P. ; Seidman, Larry J. ; Peykamian, Margaret A. / A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy. In: Schizophrenia Research. 2015 ; Vol. 164, No. 1-3. pp. 136-142.

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abstract = "This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H3 receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7weeks (4weeks titration). GSK239512 was associated with a small positive effect size (ES) on the CogState Schizophrenia Battery (CSSB) Composite Score (ES=0.29, CI=-0.40, 0.99) relative to placebo (primary endpoint). GSK239512's ES on CSSB domains were generally positive or neutral except Processing Speed, which favored placebo (ES=-0.46). Effects on the MATRICS Consensus Cognitive Battery were mostly neutral or favored placebo. GSK239512 was generally well tolerated with an adverse event profile consistent with the known class pharmacology. There was no evidence of overall beneficial effects of GSK239512 for CIAS in this population.",

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A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy

Abstract

Keywords

ASJC Scopus subject areas

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