A phase i trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors

Syma Iqbal, Heinz Josef Lenz, David R Gandara, Stephen I. Shibata, Susan Groshen, Timothy W. Synold, Edward M. Newman

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The primary objective of this trial was to establish the maximum tolerated dose (MTD) of oxaliplatin 130 mg/m2 preceded by escalating doses of docetaxel 60 mg/m2 (75, 90, 100 mg/m2) administered every 3 weeks. A total of 11 patients were entered; 10 evaluable for response: 4 stable disease (liver, ovary and esophagus) and 1 partial remission (esophagus). At dose level 1, there was 1 dose-limiting toxicity (DLT) (grade 3 allergic reaction). At dose level 2, there were 3 DLTs (3 grade 4 neutropenia, grade 3 gastritis, diarrhea, hypophosphatemia, neuro-mood). The MTD is docetaxel 60 mg/m2 with oxaliplatin 130 mg/m2.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalCancer Chemotherapy and Pharmacology
Volume72
Issue number1
DOIs
StatePublished - Jul 2013

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oxaliplatin
docetaxel
Maximum Tolerated Dose
Esophagus
Tumors
Hypophosphatemia
Gastritis
Neutropenia
Liver
Toxicity
Liver Diseases
Ovary
Diarrhea
Neoplasms
Hypersensitivity

Keywords

  • Docetaxel
  • Oxaliplatin
  • Oxaliplatin and Docetaxel
  • Phase I

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Toxicology

Cite this

A phase i trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors. / Iqbal, Syma; Lenz, Heinz Josef; Gandara, David R; Shibata, Stephen I.; Groshen, Susan; Synold, Timothy W.; Newman, Edward M.

In: Cancer Chemotherapy and Pharmacology, Vol. 72, No. 1, 07.2013, p. 85-91.

Research output: Contribution to journal › Article

Iqbal, S, Lenz, HJ, Gandara, DR, Shibata, SI, Groshen, S, Synold, TW & Newman, EM 2013, 'A phase i trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors', Cancer Chemotherapy and Pharmacology, vol. 72, no. 1, pp. 85-91. https://doi.org/10.1007/s00280-013-2171-4
Iqbal S, Lenz HJ, Gandara DR, Shibata SI, Groshen S, Synold TW et al. A phase i trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology. 2013 Jul;72(1):85-91. https://doi.org/10.1007/s00280-013-2171-4
Iqbal, Syma ; Lenz, Heinz Josef ; Gandara, David R ; Shibata, Stephen I. ; Groshen, Susan ; Synold, Timothy W. ; Newman, Edward M. / A phase i trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors. In: Cancer Chemotherapy and Pharmacology. 2013 ; Vol. 72, No. 1. pp. 85-91.
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