A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations

Zhong Min Ma, Kristina Abel, Tracy Rourke, Yichuan Wang, Chris J Miller

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (103 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.

Original languageEnglish (US)
Pages (from-to)14048-14052
Number of pages5
JournalJournal of Virology
Volume78
Issue number24
DOIs
StatePublished - Dec 2004

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
Viremia
viremia
Antiviral Agents
immune response
dosage
Infection
infection
Virus Diseases
virus transmission
seroconversion
Macaca mulatta
Cellular Immunity
cell-mediated immunity
Haplorhini
monkeys
tissue culture
cells

ASJC Scopus subject areas

  • Immunology

Cite this

A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations. / Ma, Zhong Min; Abel, Kristina; Rourke, Tracy; Wang, Yichuan; Miller, Chris J.

In: Journal of Virology, Vol. 78, No. 24, 12.2004, p. 14048-14052.

Research output: Contribution to journalArticle

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