Abstract
In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (103 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14048-14052 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 78 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 2004 |
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ASJC Scopus subject areas
- Immunology
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A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations. / Ma, Zhong Min; Abel, Kristina; Rourke, Tracy; Wang, Yichuan; Miller, Chris J.
In: Journal of Virology, Vol. 78, No. 24, 12.2004, p. 14048-14052.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations
AU - Ma, Zhong Min
AU - Abel, Kristina
AU - Rourke, Tracy
AU - Wang, Yichuan
AU - Miller, Chris J
PY - 2004/12
Y1 - 2004/12
N2 - In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (103 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.
AB - In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (103 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.
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UR - http://www.scopus.com/inward/citedby.url?scp=10044227530&partnerID=8YFLogxK
U2 - 10.1128/JVI.78.24.14048-14052.2004
DO - 10.1128/JVI.78.24.14048-14052.2004
M3 - Article
VL - 78
SP - 14048
EP - 14052
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 24
ER -