A pathologic and toxicologic evaluation of veal calves fed large amounts of zinc.

T. W. Graham, C. A. Holmberg, Carl L Keen, Mark Thurmond, M. S. Clegg

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21 Scopus citations


Tissues were examined from 26 male Holstein veal calves given large amounts of dietary zinc. All calves had been fed 706 micrograms zinc/g of milk replacer for 28 days before the first death occurred. Calves died naturally (14, group A) or were euthanatized (12, group B) after 23 days of feeding a lower concentration of zinc (150 micrograms/g). Average amounts of zinc in liver (wet weight) were 345.72 micrograms/g (group A) and 344.84 micrograms/g (group B). Mean kidney zinc concentrations were 219.0 micrograms/g (group A) and 252.38 micrograms/g (group B). Tissue manganese, copper, and iron levels were normal. Changes at necropsy included pneumonia, fluid digesta, and petechiae and infarcts in liver, kidney, and heart (as a result of bacterial infections). Histological changes that were directly attributed to dietary zinc intake were: marked atrophy and necrosis of pancreatic acinar tissue (group A); multifocal fibrosis of pancreatic acini (group B); multifocal renal cortical fibrosis with necrosis in convoluted tubules and loops of Henle, and with intratubular mineralization (groups A and B). Hepatic midzonal mineralization and fibrosis of the adrenal zona glomerulosa were seen in group B calves.

Original languageEnglish (US)
Pages (from-to)484-491
Number of pages8
JournalVeterinary Pathology
Issue number6
StatePublished - Nov 1988

ASJC Scopus subject areas

  • veterinary(all)


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