A novel sensor for high throughput preclinical radiotracer imaging

Haris Kudrolli, Harish B. Bhandari, Katherine L. Byrne, Simon R Cherry, Gregory Mitchell, Hamid Sabet, Vivek Nagarkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Preclinical imaging is a cornerstone of translational research, as all therapeutic drugs need to be tested for efficacy and toxicity on animals prior to human trials. Optical imaging techniques, such as bioluminescence and multispectral fluorescence imaging, currently dominate preclinical functional imaging despite their depth dependent limitations on quantitation and sensitivity. Translating drugs developed with these techniques to clinical models can therefore be difficult. Hence, clinically relevant nuclear imaging techniques, such as SPECT and PET, are therefore becoming increasingly used in preclinical imaging. Dedicated preclinical SPECT and PET systems are now available, but for many preclinical research groups this requires a significant investment in new equipment. We demonstrate a method to acquire high resolution planar images with a SPECT radiotracer by retrofitting a IVIS Spectrum (Caliper Life Sciences) optical imaging system with a pinhole collimator and a large area CsI:Tl scintillator with a novel morphology. We report on the development of a novel thick, transparent, crystalline microcolumnar CsI:Tl scintillator structure (Crystalline Microcolumnar Structure (CMS) scintillator) that simultaneously provides high ?-ray absorption efficiency, high intrinsic spatial resolution, and bright light emission. We present animal and phantom images acquired using a 4 mm thick, 15 cm diameter scintillator and a 2 mm diameter tungsten pinhole collimator with a IVIS Spectrum. The ability to use an existing commercial preclinical optical imaging system to rapidly acquire planar gamma ray images with good spatial resolution of one or multiple animals would be a new and useful tool for high throughput screening of molecular imaging probes.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8668
DOIs
StatePublished - 2013
EventMedical Imaging 2013: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 11 2013Feb 14 2013

Other

OtherMedical Imaging 2013: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/11/132/14/13

Keywords

  • Crystalline microcolumnar structure (CMS) scintillator
  • Molecular imaging
  • Preclinical imaging
  • Thallium doped cesium iodide (CsI:Tl)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kudrolli, H., Bhandari, H. B., Byrne, K. L., Cherry, S. R., Mitchell, G., Sabet, H., & Nagarkar, V. (2013). A novel sensor for high throughput preclinical radiotracer imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8668). [866809] https://doi.org/10.1117/12.2008165