Abstract
We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4MHz and one center 5.3MHz arrays) transducer integrated with the Siemens Antares® System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| Pages | 957-960 |
| Number of pages | 4 |
| DOIs | |
| State | Published - 2007 |
| Event | 2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States Duration: Oct 28 2007 → Oct 31 2007 |
Other
| Other | 2007 IEEE Ultrasonics Symposium, IUS |
|---|---|
| Country | United States |
| City | New York, NY |
| Period | 10/28/07 → 10/31/07 |
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Keywords
- Radiation force
- Targeted imaging
- Targeted microbubbles
- Ultrasound molecular imaging
ASJC Scopus subject areas
- Engineering(all)
Cite this
A novel sensitive targeted imaging technique for ultrasonic molecular imaging. / Zheng, Hairong; Kruse, Dustin E.; Stephens, Douglas N.; Ferrara, Katherine W.; Sutcliffe, Patrick; Gardner, Edward.
Proceedings - IEEE Ultrasonics Symposium. 2007. p. 957-960 4409817.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - A novel sensitive targeted imaging technique for ultrasonic molecular imaging
AU - Zheng, Hairong
AU - Kruse, Dustin E.
AU - Stephens, Douglas N.
AU - Ferrara, Katherine W.
AU - Sutcliffe, Patrick
AU - Gardner, Edward
PY - 2007
Y1 - 2007
N2 - We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4MHz and one center 5.3MHz arrays) transducer integrated with the Siemens Antares® System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.
AB - We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4MHz and one center 5.3MHz arrays) transducer integrated with the Siemens Antares® System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.
KW - Radiation force
KW - Targeted imaging
KW - Targeted microbubbles
KW - Ultrasound molecular imaging
UR - http://www.scopus.com/inward/record.url?scp=48149085278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48149085278&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2007.244
DO - 10.1109/ULTSYM.2007.244
M3 - Conference contribution
AN - SCOPUS:48149085278
SN - 1424413834
SN - 9781424413836
SP - 957
EP - 960
BT - Proceedings - IEEE Ultrasonics Symposium
ER -