A novel sensitive targeted imaging technique for ultrasonic molecular imaging

Hairong Zheng, Dustin E. Kruse, Douglas N. Stephens, Katherine W. Ferrara, Patrick Sutcliffe, Edward Gardner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4MHz and one center 5.3MHz arrays) transducer integrated with the Siemens Antares® System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages957-960
Number of pages4
DOIs
StatePublished - 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Other

Other2007 IEEE Ultrasonics Symposium, IUS
CountryUnited States
CityNew York, NY
Period10/28/0710/31/07

Fingerprint

Ultrasonic imaging
Molecular imaging
Imaging techniques
Ultrasonics
Acoustic emissions
Lipids
Transducers
Cellulose
Adhesion
Tissue
Radiation
Composite materials

Keywords

  • Radiation force
  • Targeted imaging
  • Targeted microbubbles
  • Ultrasound molecular imaging

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Zheng, H., Kruse, D. E., Stephens, D. N., Ferrara, K. W., Sutcliffe, P., & Gardner, E. (2007). A novel sensitive targeted imaging technique for ultrasonic molecular imaging. In Proceedings - IEEE Ultrasonics Symposium (pp. 957-960). [4409817] https://doi.org/10.1109/ULTSYM.2007.244

A novel sensitive targeted imaging technique for ultrasonic molecular imaging. / Zheng, Hairong; Kruse, Dustin E.; Stephens, Douglas N.; Ferrara, Katherine W.; Sutcliffe, Patrick; Gardner, Edward.

Proceedings - IEEE Ultrasonics Symposium. 2007. p. 957-960 4409817.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zheng, H, Kruse, DE, Stephens, DN, Ferrara, KW, Sutcliffe, P & Gardner, E 2007, A novel sensitive targeted imaging technique for ultrasonic molecular imaging. in Proceedings - IEEE Ultrasonics Symposium., 4409817, pp. 957-960, 2007 IEEE Ultrasonics Symposium, IUS, New York, NY, United States, 10/28/07. https://doi.org/10.1109/ULTSYM.2007.244
Zheng H, Kruse DE, Stephens DN, Ferrara KW, Sutcliffe P, Gardner E. A novel sensitive targeted imaging technique for ultrasonic molecular imaging. In Proceedings - IEEE Ultrasonics Symposium. 2007. p. 957-960. 4409817 https://doi.org/10.1109/ULTSYM.2007.244
Zheng, Hairong ; Kruse, Dustin E. ; Stephens, Douglas N. ; Ferrara, Katherine W. ; Sutcliffe, Patrick ; Gardner, Edward. / A novel sensitive targeted imaging technique for ultrasonic molecular imaging. Proceedings - IEEE Ultrasonics Symposium. 2007. pp. 957-960
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