Abstract
We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4MHz and one center 5.3MHz arrays) transducer integrated with the Siemens Antares® System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.
Original language | English (US) |
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Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
Pages | 957-960 |
Number of pages | 4 |
DOIs | |
State | Published - 2007 |
Event | 2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States Duration: Oct 28 2007 → Oct 31 2007 |
Other
Other | 2007 IEEE Ultrasonics Symposium, IUS |
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Country | United States |
City | New York, NY |
Period | 10/28/07 → 10/31/07 |
Keywords
- Radiation force
- Targeted imaging
- Targeted microbubbles
- Ultrasound molecular imaging
ASJC Scopus subject areas
- Engineering(all)