A novel route to fully substituted 1H-pyrazoles

Yat Fan Suen, Håkon Hope, Michael H. Nantz, Makhluf J. Haddadin, Mark J. Kurth

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.

Original languageEnglish (US)
Pages (from-to)8468-8471
Number of pages4
JournalJournal of Organic Chemistry
Volume70
Issue number21
DOIs
StatePublished - Oct 14 2005

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Pyrazoles
Cyclization
Sulfur
Extrusion
Condensation

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Suen, Y. F., Hope, H., Nantz, M. H., Haddadin, M. J., & Kurth, M. J. (2005). A novel route to fully substituted 1H-pyrazoles. Journal of Organic Chemistry, 70(21), 8468-8471. https://doi.org/10.1021/jo051319a

A novel route to fully substituted 1H-pyrazoles. / Suen, Yat Fan; Hope, Håkon; Nantz, Michael H.; Haddadin, Makhluf J.; Kurth, Mark J.

In: Journal of Organic Chemistry, Vol. 70, No. 21, 14.10.2005, p. 8468-8471.

Research output: Contribution to journalArticle

Suen, YF, Hope, H, Nantz, MH, Haddadin, MJ & Kurth, MJ 2005, 'A novel route to fully substituted 1H-pyrazoles', Journal of Organic Chemistry, vol. 70, no. 21, pp. 8468-8471. https://doi.org/10.1021/jo051319a
Suen YF, Hope H, Nantz MH, Haddadin MJ, Kurth MJ. A novel route to fully substituted 1H-pyrazoles. Journal of Organic Chemistry. 2005 Oct 14;70(21):8468-8471. https://doi.org/10.1021/jo051319a
Suen, Yat Fan ; Hope, Håkon ; Nantz, Michael H. ; Haddadin, Makhluf J. ; Kurth, Mark J. / A novel route to fully substituted 1H-pyrazoles. In: Journal of Organic Chemistry. 2005 ; Vol. 70, No. 21. pp. 8468-8471.
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