Abstract
A novel reagent (diisopropoxyphosphorylmethanesulfonylmethanesulfonylmethyl)-phosphonic acid diisopropyl ester (8) capable of forming symmetrical and non-symmetrical α,β unsaturated gem-disulfones is reported. Both aromatic and aliphatic aldehydes react in good yields to give exclusively the trans isomer. Selectivity for the mono-olefin can be achieved by varying the stoichiometry of reagents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5137-5140 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 42 |
| Issue number | 31 |
| DOIs | |
| State | Published - Jul 30 2001 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Cite this
Hadd, M. J., Smith, M., & Gervay-Hague, J. (2001). A novel reagent for the synthesis of geminal di-sulfones. Tetrahedron Letters, 42(31), 5137-5140. https://doi.org/10.1016/S0040-4039(01)01004-8