A novel reagent for the synthesis of geminal di-sulfones

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11 Scopus citations

Abstract

A novel reagent (diisopropoxyphosphorylmethanesulfonylmethanesulfonylmethyl)-phosphonic acid diisopropyl ester (8) capable of forming symmetrical and non-symmetrical α,β unsaturated gem-disulfones is reported. Both aromatic and aliphatic aldehydes react in good yields to give exclusively the trans isomer. Selectivity for the mono-olefin can be achieved by varying the stoichiometry of reagents.

Original languageEnglish (US)
Pages (from-to)5137-5140
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number31
DOIs
StatePublished - Jul 30 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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