A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome

M. Kurban, T. Cheng, M. Wajid, Maija Ht Kiuru, Y. Shimomura, A. M. Christiano

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background Papillon-Lefevre syndrome (PLS; OMlM 245000) is an autosomal recessive disease caused by mutations in cathepsin C (CTSC) gene and is characterized by palmoplantar keratoderma, psoriasiform lesion over the extensor surfaces and gingivitis followed by loss of teeth. CTSC gene is expressed in several tissues including the skin and cells of the immune system. In the skin, CTSC plays a role in differentiation and desquamation, whereas in the immune system, it activates serine proteases. Objectives We analysed the molecular basis of PLS in a Pakistani family. Methods Genomic DNA was isolated from the sample according to standard techniques. All exons of the CTSC gene with adjacent sequences of exon-intron borders were amplified by PCR and directly sequenced. Results We identified a novel deletion mutation designated c.2ldelG (Leu7PhefsX57) in exon 1 of the CTSC gene, which probably results in the absence of CTSC protein. Conclusion Our data further expand the spectrum of mutations in the CTSC gene underlying PLS.

Original languageEnglish (US)
Pages (from-to)967-969
Number of pages3
JournalJournal of the European Academy of Dermatology and Venereology
Issue number8
StatePublished - Aug 2010
Externally publishedYes


  • cathepsin C
  • gingivitis
  • palmoplantar keratoderma
  • Papillon-Lefevre syndrome

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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