A novel microreactor approach for analysis of ketones and aldehydes in breath

Xiao An Fu, Mingxiao Li, Souvik Biswas, Michael H. Nantz, Richard M. Higashi

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N- trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C 1 to C 12 aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.

Original languageEnglish (US)
Pages (from-to)4662-4666
Number of pages5
JournalAnalyst
Volume136
Issue number22
DOIs
StatePublished - Nov 21 2011
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

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    Fu, X. A., Li, M., Biswas, S., Nantz, M. H., & Higashi, R. M. (2011). A novel microreactor approach for analysis of ketones and aldehydes in breath. Analyst, 136(22), 4662-4666. https://doi.org/10.1039/c1an15618g