Abstract
The leukocyte-restricted β2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function. Despite extensive research in this field, only three members of this Integrin subfamily have been described: C011 a/CD18 (LFA-1), CD11 b/ CD18 (Mac-1), and CD11c/CD18 (p150,95). We have identified a cDNA encoding a fourth a chain, ad, that associates with C018. The ad subunit is more closely related to CD11b and CD11c than to CD11a. This integrin is expressed at moderate levels on myelomonocytic cell lines and subsets of peripheral blood leukocytes, and more strongly on tissue-compartmentalized cells such as foam cells, specialized macrophages found In aortic fatty streaks that may develop into atherosclerotic lesions. The ad/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-690 |
| Number of pages | 8 |
| Journal | Immunity |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases
Cite this
A novel leukointegrin, αdβ2, binds preferentially to ICAM-3. / Van der Vieren, Monica; Le Trong, Hai; Wood, Christi L.; Moore, Peter F; John, Tom St; Staunton, Donald E.; Gallatin, W. Michael.
In: Immunity, Vol. 3, No. 6, 1995, p. 683-690.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A novel leukointegrin, αdβ2, binds preferentially to ICAM-3
AU - Van der Vieren, Monica
AU - Le Trong, Hai
AU - Wood, Christi L.
AU - Moore, Peter F
AU - John, Tom St
AU - Staunton, Donald E.
AU - Gallatin, W. Michael
PY - 1995
Y1 - 1995
N2 - The leukocyte-restricted β2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function. Despite extensive research in this field, only three members of this Integrin subfamily have been described: C011 a/CD18 (LFA-1), CD11 b/ CD18 (Mac-1), and CD11c/CD18 (p150,95). We have identified a cDNA encoding a fourth a chain, ad, that associates with C018. The ad subunit is more closely related to CD11b and CD11c than to CD11a. This integrin is expressed at moderate levels on myelomonocytic cell lines and subsets of peripheral blood leukocytes, and more strongly on tissue-compartmentalized cells such as foam cells, specialized macrophages found In aortic fatty streaks that may develop into atherosclerotic lesions. The ad/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1.
AB - The leukocyte-restricted β2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function. Despite extensive research in this field, only three members of this Integrin subfamily have been described: C011 a/CD18 (LFA-1), CD11 b/ CD18 (Mac-1), and CD11c/CD18 (p150,95). We have identified a cDNA encoding a fourth a chain, ad, that associates with C018. The ad subunit is more closely related to CD11b and CD11c than to CD11a. This integrin is expressed at moderate levels on myelomonocytic cell lines and subsets of peripheral blood leukocytes, and more strongly on tissue-compartmentalized cells such as foam cells, specialized macrophages found In aortic fatty streaks that may develop into atherosclerotic lesions. The ad/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1.
UR - http://www.scopus.com/inward/record.url?scp=0029198299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029198299&partnerID=8YFLogxK
U2 - 10.1016/1074-7613(95)90058-6
DO - 10.1016/1074-7613(95)90058-6
M3 - Article
C2 - 8777714
AN - SCOPUS:0029198299
VL - 3
SP - 683
EP - 690
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 6
ER -