A novel iterative image reconstruction method for high-resolution PET imaging with a Monte Carlo based positron range model

Lin Fu, Jinyi Qi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Positron range is one of the fundamental factors that limit the spatial resolution of positron emission tomography (PET).While empirical expressions are available to describe positron range in homogenous media, analytical calculation of positron range in biological objects where complex bone/tissue/air boundaries exist is extremely difficult. One solution is to use Monte Carlo (MC) simulation. However, on-the-fly MC simulation of positron migration is computationally intensive and is impractical to be used in every forward and back projection operation in an iterative image reconstruction algorithm. To address this problem, we have developed a maximum a posteriori (MAP) reconstruction algorithm with residual correction capability. To reduce the computational cost, the new algorithm uses a simplified, but computationally efficient system model in reconstruction and uses MC simulation to remove the reconstruction artifacts caused by the simplified system model. "" e performed computer simulations using the Geant4 Me simulation package to validate the proposed method. The results demonstrate that the proposed method is much more computationally efficient than the traditional MC-based MAP algorithm, and produces higher resolution images than the method that uses the simplified system matrix alone.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages3609-3612
Number of pages4
DOIs
StatePublished - 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

Fingerprint

Computer-Assisted Image Processing
image reconstruction
Positron-Emission Tomography
positrons
tomography
Electrons
high resolution
simulation
Computer Simulation
Artifacts
Air
bones
artifacts
Costs and Cost Analysis
Bone and Bones
computerized simulation
spatial resolution
projection
costs
air

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

A novel iterative image reconstruction method for high-resolution PET imaging with a Monte Carlo based positron range model. / Fu, Lin; Qi, Jinyi.

IEEE Nuclear Science Symposium Conference Record. 2008. p. 3609-3612 4774100.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fu, L & Qi, J 2008, A novel iterative image reconstruction method for high-resolution PET imaging with a Monte Carlo based positron range model. in IEEE Nuclear Science Symposium Conference Record., 4774100, pp. 3609-3612, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774100
Fu, Lin ; Qi, Jinyi. / A novel iterative image reconstruction method for high-resolution PET imaging with a Monte Carlo based positron range model. IEEE Nuclear Science Symposium Conference Record. 2008. pp. 3609-3612
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