A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2

Lindsey A Loomba-Albrecht, Maryam Jame, Andrew A. Bremer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Maturity-onset diabetes of the young (MODY) is a group of disorders accounting for 2-5% of diabetes; MODY2 is caused by inactivating GCK mutations. We report a case of MODY2 caused by a novel GCK mutation and demonstrate differential glycemic/C-peptide responses to treatment with insulin, no medication, and an oral sulfonylurea.

Original languageEnglish (US)
JournalDiabetes Research and Clinical Practice
Volume87
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Glucokinase
  • MODY2
  • Sulfonylurea

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

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