A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis

Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil Kaul, Darius Schneider, Anke S. Lonsdorf, Manuela Fahrleitner, Eun Young Choi, Vanessa Dutoit, Manuela Pellegrini, Sylvia Grossklaus, Peter P. Nawroth, Gustavo Baretton, Sentot Santoso, Samuel T Hwang, Bernd Arnold, Triantafyllos Chavakis

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C-/- mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.

Original languageEnglish (US)
Pages (from-to)4096-4105
Number of pages10
JournalCancer Research
Volume71
Issue number12
DOIs
StatePublished - Jun 15 2011
Externally publishedYes

Fingerprint

Junctional Adhesion Molecule C
Melanoma
Neoplasm Metastasis
Lung
Experimental Melanomas
Transendothelial and Transepithelial Migration

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Langer, H. F., Orlova, V. V., Xie, C., Kaul, S., Schneider, D., Lonsdorf, A. S., ... Chavakis, T. (2011). A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Cancer Research, 71(12), 4096-4105. https://doi.org/10.1158/0008-5472.CAN-10-2794

A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. / Langer, Harald F.; Orlova, Valeria V.; Xie, Changping; Kaul, Sunil; Schneider, Darius; Lonsdorf, Anke S.; Fahrleitner, Manuela; Choi, Eun Young; Dutoit, Vanessa; Pellegrini, Manuela; Grossklaus, Sylvia; Nawroth, Peter P.; Baretton, Gustavo; Santoso, Sentot; Hwang, Samuel T; Arnold, Bernd; Chavakis, Triantafyllos.

In: Cancer Research, Vol. 71, No. 12, 15.06.2011, p. 4096-4105.

Research output: Contribution to journalArticle

Langer, HF, Orlova, VV, Xie, C, Kaul, S, Schneider, D, Lonsdorf, AS, Fahrleitner, M, Choi, EY, Dutoit, V, Pellegrini, M, Grossklaus, S, Nawroth, PP, Baretton, G, Santoso, S, Hwang, ST, Arnold, B & Chavakis, T 2011, 'A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis', Cancer Research, vol. 71, no. 12, pp. 4096-4105. https://doi.org/10.1158/0008-5472.CAN-10-2794
Langer HF, Orlova VV, Xie C, Kaul S, Schneider D, Lonsdorf AS et al. A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Cancer Research. 2011 Jun 15;71(12):4096-4105. https://doi.org/10.1158/0008-5472.CAN-10-2794
Langer, Harald F. ; Orlova, Valeria V. ; Xie, Changping ; Kaul, Sunil ; Schneider, Darius ; Lonsdorf, Anke S. ; Fahrleitner, Manuela ; Choi, Eun Young ; Dutoit, Vanessa ; Pellegrini, Manuela ; Grossklaus, Sylvia ; Nawroth, Peter P. ; Baretton, Gustavo ; Santoso, Sentot ; Hwang, Samuel T ; Arnold, Bernd ; Chavakis, Triantafyllos. / A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. In: Cancer Research. 2011 ; Vol. 71, No. 12. pp. 4096-4105.
@article{fd85c1408c1f4998abefdb6278a5e330,
title = "A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis",
abstract = "Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C-/- mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.",
author = "Langer, {Harald F.} and Orlova, {Valeria V.} and Changping Xie and Sunil Kaul and Darius Schneider and Lonsdorf, {Anke S.} and Manuela Fahrleitner and Choi, {Eun Young} and Vanessa Dutoit and Manuela Pellegrini and Sylvia Grossklaus and Nawroth, {Peter P.} and Gustavo Baretton and Sentot Santoso and Hwang, {Samuel T} and Bernd Arnold and Triantafyllos Chavakis",
year = "2011",
month = "6",
day = "15",
doi = "10.1158/0008-5472.CAN-10-2794",
language = "English (US)",
volume = "71",
pages = "4096--4105",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "12",

}

TY - JOUR

T1 - A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis

AU - Langer, Harald F.

AU - Orlova, Valeria V.

AU - Xie, Changping

AU - Kaul, Sunil

AU - Schneider, Darius

AU - Lonsdorf, Anke S.

AU - Fahrleitner, Manuela

AU - Choi, Eun Young

AU - Dutoit, Vanessa

AU - Pellegrini, Manuela

AU - Grossklaus, Sylvia

AU - Nawroth, Peter P.

AU - Baretton, Gustavo

AU - Santoso, Sentot

AU - Hwang, Samuel T

AU - Arnold, Bernd

AU - Chavakis, Triantafyllos

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C-/- mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.

AB - Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C-/- mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.

UR - http://www.scopus.com/inward/record.url?scp=79958863561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958863561&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-10-2794

DO - 10.1158/0008-5472.CAN-10-2794

M3 - Article

C2 - 21593193

AN - SCOPUS:79958863561

VL - 71

SP - 4096

EP - 4105

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 12

ER -