A novel first exon directs hormonesensitive transcription of the pig prolactin receptor

Anke Schennink, Josephine F. Trott, Bradley A. Freking, Russell C. Hovey

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Endocrine, paracrine, and autocrine prolactin (PRL) acts through its receptor (PRLR) to confer a wide range of biological functions, including its established role during lactation. We have identified a novel first exon of the porcine PRLR that gives rise to three different mRNA transcripts. Transcription of this first exon is tissue specific, where it increases during gestation in the adrenal glands and uterus. Within the mammary glands, its transcription is induced by estrogen and PRL, while in the uterus, its expression is downregulated by progestin. The promoter region has an enhancer element located between K453 and K424 bp and a putative repressor element between K648 and K596 bp. Estrogen, acting through the estrogen receptor, activates transcription from this promoter through both E-box and transcription factor AP-2 α binding sites. These findings support the concept that the multilevel hormonal regulation of PRLR transcription contributes to the various biological functions of PRL.

Original languageEnglish (US)
JournalJournal of Molecular Endocrinology
Issue number1
StatePublished - Apr 10 2013


  • Alternative splicing
  • Pig
  • Prolactin receptor
  • Promoter

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Medicine(all)


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