A novel chromosome segregation mechanism during female meiosis

Karen Perry McNally, Michelle T. Panzica, Taekyung Kim, Daniel B. Cortes, Francis J. McNally

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In a wide range of eukaryotes, chromosome segregation occurs through anaphase A, in which chromosomes move toward stationary spindle poles, anaphase B, in which chromosomes move at the same velocity as outwardly moving spindle poles, or both. In contrast, Caenorhabditis elegans female meiotic spindles initially shorten in the pole-to-pole axis such that spindle poles contact the outer kinetochore before the start of anaphase chromosome separation. Once the spindle pole-to-kinetochore contact has been made, the homologues of a 4-μm-long bivalent begin to separate. The spindle shortens an additional 0.5 μm until the chromosomes are embedded in the spindle poles. Chromosomes then separate at the same velocity as the spindle poles in an anaphase B-like movement. We conclude that the majority of meiotic chromosome movement is caused by shortening of the spindle to bring poles in contact with the chromosomes, followed by separation of chromosome-bound poles by outward sliding.

Original languageEnglish (US)
Pages (from-to)2576-2589
Number of pages14
JournalMolecular Biology of the Cell
Volume27
Issue number16
DOIs
StatePublished - Aug 15 2016

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Chromosome Segregation
Meiosis
Spindle Poles
Chromosomes
Anaphase
Kinetochores
Spindle Apparatus
Caenorhabditis elegans
Eukaryota

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

McNally, K. P., Panzica, M. T., Kim, T., Cortes, D. B., & McNally, F. J. (2016). A novel chromosome segregation mechanism during female meiosis. Molecular Biology of the Cell, 27(16), 2576-2589. https://doi.org/10.1091/mbc.E16-05-0331

A novel chromosome segregation mechanism during female meiosis. / McNally, Karen Perry; Panzica, Michelle T.; Kim, Taekyung; Cortes, Daniel B.; McNally, Francis J.

In: Molecular Biology of the Cell, Vol. 27, No. 16, 15.08.2016, p. 2576-2589.

Research output: Contribution to journalArticle

McNally, KP, Panzica, MT, Kim, T, Cortes, DB & McNally, FJ 2016, 'A novel chromosome segregation mechanism during female meiosis', Molecular Biology of the Cell, vol. 27, no. 16, pp. 2576-2589. https://doi.org/10.1091/mbc.E16-05-0331
McNally KP, Panzica MT, Kim T, Cortes DB, McNally FJ. A novel chromosome segregation mechanism during female meiosis. Molecular Biology of the Cell. 2016 Aug 15;27(16):2576-2589. https://doi.org/10.1091/mbc.E16-05-0331
McNally, Karen Perry ; Panzica, Michelle T. ; Kim, Taekyung ; Cortes, Daniel B. ; McNally, Francis J. / A novel chromosome segregation mechanism during female meiosis. In: Molecular Biology of the Cell. 2016 ; Vol. 27, No. 16. pp. 2576-2589.
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