A Novel and Likely Inherited Lymphoproliferative Disease in British Shorthair Kittens

D. Aberdein, J. S. Munday, R. A. Fairley, William Vernau, K. G. Thompson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

An unusual lymphoproliferative disease was identified in multiple closely related British Shorthair (BSH) kittens, suggesting an inherited predisposition to disease. Affected kittens typically developed rapidly progressive and marked generalized lymphadenopathy, moderate splenomegaly, and regenerative and likely hemolytic anemia from 6 weeks of age. Microscopic findings were suggestive of multicentric T-cell lymphoma, but additional testing revealed a polyclonal population of CD3+/CD4–/CD8– “double negative” T cells (DNT cells). This is a novel disease presentation with similarities to the human disorder autoimmune lymphoproliferative syndrome (ALPS), a rare inherited disease causing lymphoproliferation and variable manifestations of autoimmunity. The human disease is most commonly due to the presence of Fas gene mutations causing defective lymphocyte apoptosis, and further investigations of both the mode of inheritance and genetic basis for disease in affected cats are currently in progress.

Original languageEnglish (US)
Pages (from-to)1176-1182
Number of pages7
JournalVeterinary Pathology
Volume52
Issue number6
DOIs
StatePublished - Nov 1 2015

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Keywords

  • apoptosis
  • autoimmune lymphoproliferative syndrome (ALPS)
  • cat
  • genetic predisposition to disease
  • lymphadenopathy
  • lymphoma
  • lymphoproliferative disorders
  • PCR for antigen receptor rearrangement

ASJC Scopus subject areas

  • veterinary(all)

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